ArticleEuropean journal of clinical pharmacology2003
Antidepressant drug use in general practice: inter-practice variation and association with practice characteristics.
Article in European journal of clinical pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- The stratified medicalisation of mental health symptoms: educational inequalities in the use of psychotropic medication in Belgium.Social psychiatry and psychiatric epidemiology · 2023Article
- Analysis of Antidepressants Utilization for Patients Visiting Psychiatric Out-Patient Clinic in a Tertiary Care Hospital.Healthcare (Basel, Switzerland) · 2022Article
- Profiles of GPs with high and low self-reported physician empathy-personal, professional, and antibiotic prescribing characteristics.BMC primary care · 2022Article
- Visualizing nationwide variation in medicare Part D prescribing patterns.BMC medical informatics and decision making · 2018Article
- How do GP practices and patient characteristics influence the prescription of antidepressants? A cross-sectional study.Annals of general psychiatry · 2015Article
- Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications.European journal of clinical pharmacology · 2014Article
- Danish physicians' preferences for prescribing escitalopram over citalopram and sertraline to treatment-naïve patients: a national, register-based study.European journal of clinical pharmacology · 2013Article
- Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain.PloS one · 2012Article
- Antidepressants utilization among elderly in Lombardy from 2000 to 2007: dispensing trends and appropriateness.European journal of clinical pharmacology · 2011Article
- Tamoxifen's protection against breast cancer recurrence is not reduced by concurrent use of the SSRI citalopram.British journal of cancer · 2008Article
- Newer antidepressant drug use in East Asian psychiatric treatment settings: REAP (Research on East Asia Psychotropic Prescriptions) Study.British journal of clinical pharmacology · 2007Article
- Prevalence and patterns of antidepressant drug use during pregnancy.European journal of clinical pharmacology · 2006Article
- Socio-economic inequalities in first-time use of antidepressants: a population-based study.European journal of clinical pharmacology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe use of antidepressants (ADs) has escalated and prompted considerable debate. Many depressed patients go unrecognised or under-treated and the area of indication of the new ADs is widening. The aim of this study was to analyse (i). the variation in general practitioners' prescribing of ADs by comparing with prescribing of other drug groups and (ii). whether the general prescribing behaviour, practice activity and demography are associated with the AD prescribing.
methodsAnalysis of AD prescribing patterns among 174 general practices (93.5%) in the County of Funen, Denmark. Age- and sex-standardised 1-year incidences and prevalences of AD prescribing for patients listed were calculated using individual prescription data from Odense University Pharmacoepidemiologic Database. Data about health services and practice demography were obtained from the Health Insurance Register. The variation in AD 1-year prevalence was compared with other drug groups by a variation index (90%/10% percentile). Univariate linear regression analysis was used to examine associations between practice characteristics and prescribing.
resultsThe 1-year prevalence of AD prescribing varied sixfold, no more than the prevalence of five other drug groups. Practices with high yearly: general prescribing prevalence, mean number of drugs per medicated patient, number of surgery consultations/100 patients and counsellings/100 surgery consultations showed the highest yearly prevalence of AD prescribing. Single-handed practices had higher AD prescribing rates than partnerships. The relative use of selective serotonin re-uptake inhibitors and other new ADs showed only little variation (10% and 90% percentiles as close as 66-86%), but practices with high 1-year prevalence and incidence most often chose the new ADs.
conclusionAnalysis of inter-practice variation showed no extraordinary quality problems with regard to AD prescribing, but does not exclude that there might be problems. The general prescribing pattern of the general practitioners seems essential to their attitude to AD prescribing. The relationship between counselling and prescribing was a feature specific to ADs and deserves further investigation. Quality indicators are needed to understand differences in AD prescribing, and studies based on prescription data have to be supplemented with individual clinical data.
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