ArticleHistochemistry and cell biology2003
Myenteric nitrergic neurons along the rat esophagus: evidence for regional and strain differences in age-related changes.
Article in Histochemistry and cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- The human colon: Evidence for degenerative changes during aging and the physiological consequences.Neurogastroenterology and motility · 2025Review
- Review
- The Aging Enteric Nervous System.International journal of molecular sciences · 2023Review
- Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function.Frontiers in neuroscience · 2021Article
- Changes in neuromuscular structure and functions of human colon during ageing are region-dependent.Gut · 2019Article
- Article
- Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal Motility.Cellular and molecular gastroenterology and hepatology · 2016Article
- Excitatory and inhibitory enteric innervation of horse lower esophageal sphincter.Histochemistry and cell biology · 2015Article
- Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection.Frontiers in aging neuroscience · 2014Article
- The aging colon: the role of enteric neurodegeneration in constipation.Current gastroenterology reports · 2010Review
- Effect of age on the enteric nervous system of the human colon.Neurogastroenterology and motility · 2009Article
- Innervation of the gastrointestinal tract: patterns of aging.Autonomic neuroscience : basic & clinical · 2007Review
- Morphology of VIP/nNOS-immunoreactive myenteric neurons in the human gut.Histochemistry and cell biology · 2006Article
- News and views in Histochemistry and Cell Biology.Histochemistry and cell biology · 2004Review
- Innovative techniques and applications in histochemistry and cell biology.Histochemistry and cell biology · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have suggested an age-related reduction in the number of myenteric neurons in the lower gastrointestinal (GI) tract linked to changes in GI neuromuscular functions. The present study, combining protein gene product 9.5 immunostaining and NADPH-diaphorase histochemistry, aimed at quantifying the proportion of nitrergic neurons compared to the overall number of enteric neurons in the esophagus of young (3-4.5 months) and aged (18-20 months) Sprague-Dawley and Wistar rats. In both strains, the neuron numbers per ganglion in the cervical region were almost twice as high as in the other esophageal regions. Irrespective of age or strain, the esophagus harbored a very high proportion of intrinsic nitrergic neurons (greater than approximately 65%). Both strains showed with aging an overall neuronal loss of approximately 27%. While a significant increase (young: 64-71%; aged: 82-89%) was observed in all esophageal regions in the Wistar strain, the proportion of nitrergic neurons remained stable with aging in the Sprague-Dawley strain (range: 72-82%). In conclusion, the age-related reduction in the overall number of myenteric, nitrergic, and non-nitrergic neurons observed in the rat esophagus, appears to be highly region- and strain-dependent. Therefore, a protective mechanism against neuronal cell loss, selectively present in specific (nitrergic) enteric subpopulations, as suggested in earlier reports, cannot be put forward as a general phenomenon throughout the entire GI tract.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.