ReviewPediatric nephrology (Berlin, Germany)2003
Renal function following hematological stem cell transplantation in childhood.
Review in Pediatric nephrology (Berlin, Germany), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Incidence of acute kidney injury after hematopoietic stem cell transplantation in children: a systematic review and meta-analysis.European journal of pediatrics · 2023Pooled it
- Late renal, liver, endocrine, and cardiac outcomes of bone marrow transplantation in Kurdish children with β-thalassemia major.International journal of hematology · 2026Article
- Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus.Pediatric nephrology (Berlin, Germany) · 2022Review
- Teenagers and young adults with a past of allogenic hematopoietic stem cell transplantation are at significant risk of chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Article
- Outcomes of kidney injury including dialysis and kidney transplantation in pediatric oncology and hematopoietic cell transplant patients.Pediatric nephrology (Berlin, Germany) · 2021Article
- Impact of Acute Kidney Injury on Critically Ill Children and Neonates.Frontiers in pediatrics · 2021Review
- Post-transplant multimorbidity index and quality of life in patients with chronic graft-versus-host disease-results from a joint evaluation of a prospective German multicenter validation trial and a cohort from the National Institutes of Health.Bone marrow transplantation · 2021Article
- Acute Kidney Injury and the Risk of Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016Article
- Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children.Clinical pharmacokinetics · 2015Review
- Solid organ transplantation following end-organ failure in recipients of hematopoietic stem cell transplantation in children.Pediatric nephrology (Berlin, Germany) · 2014Review
- Acute graft-versus-host disease of the kidney in allogeneic rat bone marrow transplantation.PloS one · 2014Article
- Risk factors associated with pediatric intensive care unit admission and mortality after pediatric stem cell transplant: possible role of renal involvement.World journal of pediatrics : WJP · 2013Article
- Implications of different fluid overload definitions in pediatric stem cell transplant patients requiring continuous renal replacement therapy.Intensive care medicine · 2012Article
- Early occurrence of nephrotic syndrome associated with cord blood stem cell transplantation.Clinical and experimental nephrology · 2012Article
- Renal tubule function in beta-thalassemia after hematopoietic stem cell transplantation.Pediatric nephrology (Berlin, Germany) · 2009Article
- Nephrotoxicity as a cause of acute kidney injury in children.Pediatric nephrology (Berlin, Germany) · 2008Review
- Long-term renal function after hemopoietic stem cell transplantation in children.Bone marrow transplantation · 2005Article
- Granulomatous interstitial nephritis associated with bone marrow transplantation.Pediatric nephrology (Berlin, Germany) · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal function greatly influences mortality rates in the early phase following hematological stem cell transplantation (HSCT) in childhood, as well as the quality of life in long-term survivors. Nevertheless, the number of studies in pediatric populations is limited and some important aspects of kidney function after HSCT have only been elucidated in adults. The incidence of acute renal failure (ARF) immediately after HSCT in pediatric patients is between 25% and 50%, with 5%-10% of children requiring renal replacement therapy. Doubling of serum creatinine is associated with a twofold increase in mortality. However, the need for dialysis leads to a further increase in mortality rates to 80%-90%. Specific renal syndromes appear at different times following HSCT, revealing a similar pattern in children and adult patients. In both children and adults, impaired renal function associated with liver impairment (hepatorenal syndrome) is the most important cause for ARF. Therapeutic approaches have not been able to reduce the frequency or to improve outcome so far. In adults surviving long term, bone marrow transplant (BMT) nephropathy is the most frequent renal complication, although a considerable variation in incidence (up to 70%) has been published, partly due to various definitions and manifestations. Little is known about the long-term outcome of renal function in patients treated with HSCT in childhood. However, chronic renal failure has been reported in 0%-28%, but no end-stage renal failure has been published so far. Tubular function following HSCT is rarely investigated, although its impact on long-term survivors of BMT in childhood might be of some importance, especially for growth and bone metabolism.
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