ArticleJournal of virology2003
Induction of broad and potent anti-human immunodeficiency virus immune responses in rhesus macaques by priming with a DNA vaccine and boosting with protein-adsorbed polylactide coglycolide microparticles.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- MicroRNA replacement therapy in cancer.Journal of cellular physiology · 2019Review
- Biodegradable polylactide microspheres enhance specific immune response induced by Hepatitis B surface antigen.Human vaccines & immunotherapeutics · 2014Article
- Engineering synthetic vaccines using cues from natural immunity.Nature materials · 2013Review
- Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine.PloS one · 2012Article
- Article
- Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant.Journal of virology · 2010Article
- Preparation and characterization of innovative protein-coated poly(methylmethacrylate) core-shell nanoparticles for vaccine purposes.Pharmaceutical research · 2007Article
- Induction of potent CD8+ T-cell responses by novel biodegradable nanoparticles carrying human immunodeficiency virus type 1 gp120.Journal of virology · 2007Article
- Antigen expression kinetics and immune responses of mice immunized with noninfectious simian-human immunodeficiency virus DNA.Journal of virology · 2005Article
- Enhanced potency of plasmid DNA microparticle human immunodeficiency virus vaccines in rhesus macaques by using a priming-boosting regimen with recombinant proteins.Journal of virology · 2005Article
- Non-human primate models for AIDS vaccine research.Current drug targets. Infectious disorders · 2005Review
- Novel approaches to vaccine delivery.Pharmaceutical research · 2004Review
- Progress on new vaccine strategies against chronic viral infections.The Journal of clinical investigation · 2004Review
- Design of amine-modified graft polyesters for effective gene delivery using DNA-loaded nanoparticles.Pharmaceutical research · 2004Article
- DNA vaccines against human immunodeficiency virus type 1 in the past decade.Clinical microbiology reviews · 2004Review
- Recent advances in the discovery and delivery of vaccine adjuvants.Nature reviews. Drug discovery · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad and strong immune responses, these were achieved by priming with Gag DNA and boosting with Gag protein adsorbed to polylactide coglycolide microparticles. This regimen elicited strong antibodies, helper T cells, and cytotoxic T lymphocytes and thus holds promise as an effective vaccination scheme.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.