ArticleJournal of virology2003
The latency-associated nuclear antigen homolog of herpesvirus saimiri inhibits lytic virus replication.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Self-Repairing Herpesvirus Saimiri Deletion Variants.Viruses · 2022Article
- Identification of AIDS-Associated Kaposi Sarcoma: A Functional Genomics Approach.Frontiers in genetics · 2019Article
- The Critical Role of Genome Maintenance Proteins in Immune Evasion During Gammaherpesvirus Latency.Frontiers in microbiology · 2018Review
- Herpesvirus saimiri antagonizes nuclear domain 10-instituted intrinsic immunity via an ORF3-mediated selective degradation of cellular protein Sp100.Journal of virology · 2012Article
- The insulator protein CTCF binding sites in the orf73/LANA promoter region of herpesvirus saimiri are involved in conferring episomal stability in latently infected human T cells.Journal of virology · 2012Article
- The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.Future microbiology · 2011Review
- Genome-wide histone acetylation profiling of Herpesvirus saimiri in human T cells upon induction with a histone deacetylase inhibitor.Journal of virology · 2011Article
- Targeting mitotic chromosomes: a conserved mechanism to ensure viral genome persistence.Proceedings. Biological sciences · 2009Review
- ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication.Journal of virology · 2007Article
- Histone modification pattern of the T-cellular Herpesvirus saimiri genome in latency.Journal of virology · 2007Article
- Structure and function of latency-associated nuclear antigen.Current topics in microbiology and immunology · 2007Review
- Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.Journal of virology · 2006Article
- Raman spectroscopy: the gateway into tomorrow's virology.Virology journal · 2006Review
- Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription.Journal of virology · 2006Article
- Activation of the Kaposi's sarcoma-associated herpesvirus major latency locus by the lytic switch protein RTA (ORF50).Journal of virology · 2005Article
- Whole-genome transcription profiling of rhesus monkey rhadinovirus.Journal of virology · 2005Article
- Regulated and constitutive expression of anti-inflammatory cytokines by nontransforming herpesvirus saimiri vectors.Gene therapy · 2005Article
- The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activation.Journal of virology · 2005Article
- Marker gene transfer into human haemopoietic cells using a herpesvirus saimiri-based vector.Gene therapy · 2005Article
- ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herpesvirus saimiri (HVS), a T-lymphotropic tumor virus of neotropical primates, and the Kaposi's sarcoma-associated human herpesvirus 8 (KSHV) belong to the gamma-(2)-herpesvirus (Rhadinovirus) subfamily and share numerous features of genome structure and organization. The KSHV latency-associated nuclear antigen (LANA) protein appears to be relevant for viral persistence, latency, and transformation. It binds to DNA, colocalizes with viral episomal DNA, and presumably mediates efficient persistence of viral genomes. LANA further represses the transcriptional and proapoptotic activities of the p53 tumor suppressor protein. Here we report on the ORF73 gene of HVS strain C488, which is the positional and structural homolog of KSHV LANA. The ORF73 gene in OMK cells can encode a 62-kDa protein that localizes to the nucleus in a pattern similar to that of LANA. We show that the ORF73 gene product can regulate viral gene expression by acting as a transcriptional modulator of latent and lytic viral promoters. To define the HVS ORF73 function in the background of a replication-competent virus, we constructed a viral mutant that expresses ORF73 under the transcriptional control of a mifepristone (RU-486)-inducible promoter. The HVS ORF73 gene product efficiently suppresses lytic viral replication in permissive cells, indicating that it defines a critical control point between viral persistence and lytic replication.
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