ArticleJournal of virology2003
Positive regulation of CXCR4 expression and signaling by interleukin-7 in CD4+ mature thymocytes correlates with their capacity to favor human immunodeficiency X4 virus replication.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment.The Journal of clinical investigation · 2009Trial
- HIV Impacts CD34Frontiers in immunology · 2019Article
- Adaptive Immunodeficiency in WHIM Syndrome.International journal of molecular sciences · 2018Review
- Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment.Cancer discovery · 2018Article
- Homing receptor expression is deviated on CD56+ blood lymphocytes during pregnancy in Type 1 diabetic women.PloS one · 2015Article
- Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.PLoS pathogens · 2013Article
- Altered responses to homeostatic cytokines in patients with idiopathic CD4 lymphocytopenia.PloS one · 2013Article
- Regulated expression of CXCR4 constitutive active mutants revealed the up-modulated chemotaxis and up-regulation of genes crucial for CXCR4 mediated homing and engraftment of hematopoietic stem/progenitor cells.Journal of stem cells & regenerative medicine · 2013Article
- Recombinant IL-7/HGFβ efficiently induces transplantable murine hematopoietic stem cells.The Journal of clinical investigation · 2012Article
- Transforming growth factor-beta1 upregulates the expression of CXC chemokine receptor 4 (CXCR4) in human breast cancer MCF-7 cells.Acta pharmacologica Sinica · 2010Article
- Article
- Relationship between HIV coreceptor tropism and disease progression in persons with untreated chronic HIV infection.Journal of acquired immune deficiency syndromes (1999) · 2009Article
- Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors.World journal of gastroenterology · 2008Review
- Immunopathogenesis of feline immunodeficiency virus infection in the fetal and neonatal cat.Frontiers in bioscience : a journal and virtual library · 2007Review
- Naive T-cell depletion related to infection by X4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy.Journal of virology · 2006Article
- Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.Journal of virology · 2006Article
- The thymus is a common target organ in infectious diseases.PLoS pathogens · 2006Review
- Article
- Interleukin 7 increases human immunodeficiency virus type 1 LAI-mediated Fas-induced T-cell death.Journal of virology · 2005Article
- Thymic function in HIV infection.Current HIV/AIDS reports · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of X4 human immunodeficiency virus type 1 (HIV-1) variants in infected individuals is associated with poor prognosis. One of the possible causes of this emergence might be the selection of X4 variants in some specific tissue compartment. We demonstrate that the thymic microenvironment favors the replication of X4 variants by positively modulating the expression and signaling of CXCR4 in mature CD4(+) CD8(-) CD3(+) thymocytes. Here, we show that the interaction of thymic epithelial cells (TEC) with these thymocytes in culture induces an upregulation of CXCR4 expression. The cytokine secreted by TEC, interleukin-7 (IL-7), increases cell surface expression of CXCR4 and efficiently overcomes the downregulation induced by SDF-1 alpha, also produced by TEC. IL-7 also potentiates CXCR4 signaling, leading to actin polymerization, a process necessary for virus entry. In contrast, in intermediate CD4(+) CD8(-) CD3(-) thymocytes, the other subpopulation known to allow virus replication, TEC or IL-7 has little or no effect on CXCR4 expression and signaling. CCR5 is expressed at similarly low levels in the two thymocyte subpopulations, and neither its expression nor its signaling was modified by the cytokines tested. This positive regulation of CXCR4 by IL-7 in mature CD4(+) thymocytes correlates with their high capacity to favor X4 virus replication compared with intermediate thymocytes or peripheral blood mononuclear cells. Indeed, we observed an enrichment of X4 viruses after replication in thymocytes initially infected with a mixture of X4 (NL4-3) and R5 (NLAD8) HIV strains and after the emergence of X4 variants from an R5 primary isolate during culture in mature thymocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.