ArticleJournal of clinical pathology2003
Association between histology grade, expression of HsMCM2, and cyclin A in human invasive breast carcinomas.
Article in Journal of clinical pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients.British journal of cancer · 2007Pooled it
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- Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells.Journal of experimental & clinical cancer research : CR · 2018Article
- Prognostic significance of lymphatic vessel invasion diagnosed by D2-40 in Chinese invasive breast cancers.Medicine · 2017Article
- Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer.Oncology letters · 2017Article
- Integrated analysis of differentially expressed genes and pathways in triple‑negative breast cancer.Molecular medicine reports · 2017Article
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- Influence of Hormone Receptor Status on Spinal Metastatic Lesions in Patients with Breast Cancer.World neurosurgery · 2016Article
- Cyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cells.The Journal of steroid biochemistry and molecular biology · 2014Article
- Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides.PloS one · 2013Article
- Novel molecular markers of malignancy in histologically normal and benign breast.Pathology research international · 2011Article
- Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth.Molecular cancer therapeutics · 2011Article
- Local cell proliferation in rheumatoid synovial tissue: analysis by cyclin expression.Clinical rheumatology · 2006Article
- Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides.British journal of cancer · 2006Article
- Measuring proliferation in breast cancer: practicalities and applications.Breast cancer research : BCR · 2006Review
- Prognostic value of proliferation in invasive breast cancer: a review.Journal of clinical pathology · 2004Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIncreased proliferation of tumour cells has prognostic value in human invasive breast carcinomas (IBCs), and high histology grade and cyclin A expression, which may reflect high proliferation rate, are associated with poor prognosis. Expression of HsMCM2 is related to cell proliferation. This study evaluates the correlation between the expression of cyclins A, D1, D3, and E, Ki-67, proliferating cell nuclear antigen (PCNA), histology grade, and HsMCM2 expression, in addition to the independent prognostic value of HsMCM2 expression in human IBCs.
methodsImmunohistochemistry to evaluate HsMCM2, Ki-67, and PCNA expression in tumours from 147 patients with IBC.
resultsNuclear staining for HsMCM2 was seen in 10-30% of the tumour cells in 30 samples, in 30-70% in 40 samples, in > 70% in 44 samples, and in < 10% in 33 samples. One way ANOVA showed a significant association between expression of HsMCM2 and cyclin A, D3, E, histology grade, and Ki-67. A borderline correlation was seen between HsMCM2 and PCNA. In multivariate analysis, the only association was with cyclin A, in addition to a borderline association with histology grade. In a Cox regression hazards model, expression of HsMCM2 was associated with poor patient survival, although it lost its independent prognostic value when cyclin A expression was included. Ki-67 and PCNA expression were not associated with patient survival.
conclusionCyclin A expression is independently associated with HsMCM2 expression, histology grade, and Ki-67. HsMCM2 expression is associated with poor patient survival, although it loses prognostic value when adjusted for cyclin A.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.