ArticleArchives of disease in childhood. Fetal and neonatal edition2003
Decreased neutrophil apoptosis in tracheal fluids of preterm infants at risk of chronic lung disease.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Intratracheal Clara cell secretory protein (CCSP) administration in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2011Pooled it
- The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants.Thorax · 2003Trial
- Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants.BMC pediatrics · 2023Article
- Meconium Aspiration Syndrome in Animal Models: Inflammatory Process, Apoptosis, and Surfactant Inactivation.Animals : an open access journal from MDPI · 2022Review
- Effect of hypertensive disorders of pregnancy on peripheral venous blood cell count in preterm infants with a gestational age of 28-34 weeks.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Cyclooxygenase-2 in newborn hyperoxic lung injury.Free radical biology & medicine · 2013Article
- Flice inhibitory protein is associated with the survival of neonatal neutrophils.Pediatric research · 2011Article
- Neonatal neutrophils with prolonged survival secrete mediators associated with chronic inflammation.Neonatology · 2010Article
- Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils.Pediatric research · 2009Article
- Dysfunction of innate immunity and associated pathology in neonates.Indian journal of pediatrics · 2007Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the hypothesis that preterm infants who are more susceptible to lung damage have decreased neutrophil apoptosis, and to explore its relation to interleukin 10 (IL10) concentration.
designProspective cohort design. PATIENTS: One hundred tracheal fluid specimens from 50 week-1 ventilated infants were examined for IL10 (by enzyme linked immunosorbent assay) and neutrophil apoptosis (by light microscopy).
resultsNeutrophil apoptosis was absent or less than 0.22% (median 0%) in the 11 infants with chronic lung disease (CLD) (24-31 weeks gestation) during the first 4 days of life. This was significantly lower than that of the 20 preterm infants without CLD (27-31 weeks gestation; median 0.47%, range 0-1.25%) and 19 term infants (median 0.5%, range 0-2.25%). There was an increase in apoptosis in infants with CLD (median 0.44%, p = 0.046) during days 5-7. Few infants without CLD were intubated beyond 4 days. Median apoptosis on days 5-7 was 0.26% and 2.78% for non-CLD preterm and term infants, but differences were not significant. IL10 concentration in tracheal fluid of infants with CLD was less than 5 pg/ml. None of the infants with IL10 greater than 5 pg/ml developed CLD. The range of IL10 concentrations in tracheal fluid from infants without CLD was wide (0-938 pg/ml). There was no apparent correlation between IL10 levels and percentage neutrophil apoptosis in infants without CLD.
conclusionPreterm infants with low levels of IL10 and neutrophil apoptosis may be predisposed to disordered lung repair. Further studies into the method of disposal of senescent neutrophils within preterm lungs are required.
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