ArticleBiophysical journal2003
Effects of permeant ion concentrations on the gating of L-type Ca2+ channels in hair cells.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Vestibular Extremely Low-Frequency Magnetic and Electric Stimulation Effects on Human Subjective Visual Vertical Perception.Bioelectromagnetics · 2022Article
- Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells.Faculty reviews · 2020Review
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- Variations in CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Aftereffects of Intense Low-Frequency Sound on Spontaneous Otoacoustic Emissions: Effect of Frequency and Level.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Changes of ribbon synapses number of cochlear hair cells in C57BL/6J mice with age(Δ).International journal of clinical and experimental medicine · 2015Article
- Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea.PloS one · 2014Article
- Posthearing Ca(2+) currents and their roles in shaping the different modes of firing of spiral ganglion neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Energy variational analysis of ions in water and channels: Field theory for primitive models of complex ionic fluids.The Journal of chemical physics · 2010Article
- Release and elementary mechanisms of nitric oxide in hair cells.Journal of neurophysiology · 2010Article
- Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx.The Journal of biological chemistry · 2010Article
- Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells.The Journal of physiology · 2010Article
- Effects of strontium on the permeation and gating phenotype of calcium channels in hair cells.Journal of neurophysiology · 2008Article
- Molecular identity and functional properties of a novel T-type Ca2+ channel cloned from the sensory epithelia of the mouse inner ear.Journal of neurophysiology · 2008Article
- Mechanisms underlying the temporal precision of sound coding at the inner hair cell ribbon synapse.The Journal of physiology · 2006Review
- Synaptic transmission at retinal ribbon synapses.Progress in retinal and eye research · 2005Review
- Expression and functional phenotype of mouse ERG K+ channels in the inner ear: potential role in K+ regulation in the inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells.The Journal of physiology · 2004Article
- Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice.The Journal of physiology · 2003Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We determined the gating and permeation properties of single L-type Ca(2+) channels, using hair cells and varying concentrations (5-70 mM) of the charge carriers Ba(2+) and Ca(2+). The channels showed distinct gating modes with high- and low-open probability. The half-activation voltage (V(1/2)) shifted in the hyperpolarizing direction from high to low permeant ion concentrations consistent with charge screening effects. However, the differences in the slope of the voltage shifts (in VM(-1)) between Ca(2+) (0.23) and Ba(2+) (0.13), suggest that channel-ion interaction may also contribute to the gating of the channel. We examined the effect of mixtures of Ba(2+) and Ca(2+) on the activation curve. In 5 mM Ca(2+), the V(1/2) was, -26.4 +/- 2.0 mV compared to Ba(2+), -34.7 +/- 2.9 mV, as the charge carrier. However, addition of 1 mM Ba(2+) in 4 mM Ca(2+), a molar ratio, which yielded an anomalous-mole fraction effect, was sufficient to shift the V(1/2) to -34.7 +/- 1.5 mV. Although Ca(2+)-dependent inactivation of the L-type channels in hair cells can yield the present findings, we provide evidence that the anomalous gating of the channel may stem from the closed interaction between ion permeation and gating.
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