ArticleBiophysical journal2003
Perfect and near-perfect adaptation in a model of bacterial chemotaxis.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Network topology creates independent control of multiple checkpoints in the cell cycle system.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Time-reversal symmetry breaking in the chemosensory array reveals a general mechanism for dissipation-enhanced cooperative sensing.Nature communications · 2024Article
- Homeostasis in networks with multiple inputs.Journal of mathematical biology · 2024Article
- Discovering adaptation-capable biological network structures using control-theoretic approaches.PLoS computational biology · 2022Article
- Sequential modification of bacterial chemoreceptors is key for achieving both accurate adaptation and high gain.Nature communications · 2020Article
- Modeling aerotaxis band formation in Azospirillum brasilense.BMC microbiology · 2019Article
- Motor Adaptive Remodeling Speeds Up Bacterial Chemotactic Adaptation.Biophysical journal · 2018Article
- Adaptation of Living Systems.Annual review of condensed matter physics · 2018Article
- Ultrasensitivity and fluctuations in the Barkai-Leibler model of chemotaxis receptors in Escherichia coli.PloS one · 2017Article
- Information processing in bacteria: memory, computation, and statistical physics: a key issues review.Reports on progress in physics. Physical Society (Great Britain) · 2016Review
- Transient response characteristics in a biomolecular integral controller.IET systems biology · 2016Article
- Quantification of Interactions between Dynamic Cellular Network Functionalities by Cascaded Layering.PLoS computational biology · 2015Article
- Article
- Adaptive Responses Limited by Intrinsic Noise.PloS one · 2015Article
- A network characteristic that correlates environmental and genetic robustness.PLoS computational biology · 2014Article
- Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters.BMC systems biology · 2014Article
- Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation.International journal of molecular sciences · 2013Article
- Physical constraints on biological integral control design for homeostasis and sensory adaptation.Biophysical journal · 2013Article
- Adaptation dynamics in densely clustered chemoreceptors.PLoS computational biology · 2013Article
- Quantitative modeling of bacterial chemotaxis: signal amplification and accurate adaptation.Annual review of biophysics · 2013Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The signaling apparatus mediating bacterial chemotaxis can adapt to a wide range of persistent external stimuli. In many cases, the bacterial activity returns to its prestimulus level exactly, and this perfect adaptability is robust against variations in various chemotaxis protein concentrations. We model the bacterial chemotaxis signaling pathway, from ligand binding to CheY phosphorylation. By solving the steady-state equations of the model analytically, we derive a full set of conditions for the system to achieve perfect adaptation. The conditions related to the phosphorylation part of the pathway are discovered for the first time, while other conditions are generalizations of the ones found in previous works. Sensitivity of the perfect adaptation is evaluated by perturbing these conditions. We find that, even in the absence of some of the perfect adaptation conditions, adaptation can be achieved with near-perfect precision as a result of the separation of scales in both chemotaxis protein concentrations and reaction rates, or specific properties of the receptor distribution in different methylation states. Since near-perfect adaptation can be found in much larger regions of the parameter space than that defined by the perfect adaptation conditions, their existence is essential to understand robustness in bacterial chemotaxis.
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