ArticleWorld journal of gastroenterology2003
Expression of survivin protein in human colorectal carcinogenesis.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis.PloS one · 2013Pooled it
- Carbonic Anhydrase IX and Survivin in Colorectal Adenocarcinoma Cells: Slovakian Population Study.Biology · 2021Article
- Effects of thalidomide on growth and VEGF-A expression in SW480 colon cancer cells.Oncology letters · 2018Article
- Endocrine therapy inhibits proliferation and migration, promotes apoptosis and suppresses survivin protein expression in colorectal cancer cells.Molecular medicine reports · 2017Article
- The X-linked inhibitor of apoptosis protein is an independent prognostic marker for rectal adenocarcinoma after preoperative chemoradiotherapy.Virchows Archiv : an international journal of pathology · 2016Article
- Treatment of LS174T colorectal cancer stem-like cells with n-3 PUFAs induces growth suppression through inhibition of survivin expression and induction of caspase-3 activation.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer.British journal of cancer · 2014Article
- A comprehensive look at transcription factor gene expression changes in colorectal adenomas.BMC cancer · 2014Article
- Expression of survivin and its four splice variants in colorectal cancer and its clinical significances.Medical oncology (Northwood, London, England) · 2013Article
- Cotransfection of survivin and CD44v3 short hairpin RNAs affects proliferation, apoptosis, and invasiveness of colorectal cancer.Digestive diseases and sciences · 2013Article
- Risk factors for postoperative recurrence in patients with pathologically T1 colorectal cancer.World journal of surgery · 2012Article
- Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB.Experimental & molecular medicine · 2011Article
- Expression of the antiapoptotic protein survivin in colon cancer.Clinical colorectal cancer · 2011Article
- Survivin expression in colorectal carcinomas: correlations with clinicopathological parameters and survival.Digestive diseases and sciences · 2010Article
- Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer.International journal of colorectal disease · 2009Article
- Induction of apoptosis of human colon cancer cells by siRNA recombinant expression vector targeting survivin gene.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2009Article
- The influence of survivin shRNA on the cell cycle and the invasion of SW480 cells of colorectal carcinoma.Journal of experimental & clinical cancer research : CR · 2008Article
- Role of survivin and its splice variants in tumorigenesis.British journal of cancer · 2005Review
- Expression of survivin in primary and metastatic gastric cancer cells obtained by laser capture microdissection.World journal of gastroenterology · 2004Article
- Expression of survivin and its significance in colorectal cancer.World journal of gastroenterology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify the role of survivin in colorectal carcinogenesis and the relationship between Survivin and histological differentiation grade of colorectal carcinoma.
methodsImmunohistochemical staining of survivin by using the monoclonal antibody was performed by the standard streptavidin-peroxidase (SP) technique for the 188 paraffin sections which included 30 normal colorectal mucosas, 41 adenomas with low grade dysplasia, 30 adenomas with high grade dysplasia, and 87 colorectal carcinomas which were classified as high, middle and low differentiated subgroups which included 33, 28, 26 cases respectively.
resultsExpression of survivin was observed in the cytoplasm of adenoma with dysplasia and colorectal carcinoma cells. No immunoreactivity of survivin was seen in normal mucosas. The positive rate of survivin increased in the transition from normal mucosas to adenomas with low grade dysplasia to high grade dysplasia/ carcinomas (0.0 %, 31.7 %, 56.7 % and 63.2% respectively). But the difference between high grade dysplasia and carcinomas had no statistical significance. Positive rate was not related to histological differentiation grade of colorectal carcinoma. Moreover, there was no correlation between histological differentiation grade of colorectal carcinoma and immunoreactive intensity of survivin.
conclusionThe expression of survivin is the essential event in the early stage of colorectal carcinogenesis and plays an important role in the transition sequence and it is not related to histological differentiation grade of colorectal carcinoma. It thus may provide a new diagnostic and therapeutic target in colorectal cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.