ArticleEMBO reports2003
Maintenance of the correct open reading frame by the ribosome.
Article in EMBO reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Microglial Dysfunction Induced by C9ORF72 Dipeptide Repeat Proteins: Biomarker and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Deficiency of mitoribosomal S10 protein affects translation and splicing in Arabidopsis mitochondria.Nucleic acids research · 2019Article
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- Article
- Codon-Anticodon Recognition in the Bacillus subtilis glyQS T Box Riboswitch: RNA-DEPENDENT CODON SELECTION OUTSIDE THE RIBOSOME.The Journal of biological chemistry · 2015Article
- Article
- Selection for minimization of translational frameshifting errors as a factor in the evolution of codon usage.Nucleic acids research · 2009Article
- A gripping tale of ribosomal frameshifting: extragenic suppressors of frameshift mutations spotlight P-site realignment.Microbiology and molecular biology reviews : MMBR · 2009Review
- Recoding of translation in turtle mitochondrial genomes: programmed frameshift mutations and evidence of a modified genetic code.Journal of molecular evolution · 2008Article
- A new kinetic model reveals the synergistic effect of E-, P- and A-sites on +1 ribosomal frameshifting.Nucleic acids research · 2008Article
- The tri-frame model.Journal of theoretical biology · 2008Article
- Alterations in the two globular domains or in the connecting alpha-helix of bacterial ribosomal protein L9 induces +1 frameshifts.Journal of bacteriology · 2007Article
- Article
- Evolutionary specialization of recoding: frameshifting in the expression of S. cerevisiae antizyme mRNA is via an atypical antizyme shift site but is still +1.RNA (New York, N.Y.) · 2006Article
- Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects.Genome research · 2005Article
- A "gain of function" mutation in a protein mediates production of novel modified nucleosides.The EMBO journal · 2005Article
- A reduced level of charged tRNAArgmnm5UCU triggers the wild-type peptidyl-tRNA to frameshift.RNA (New York, N.Y.) · 2005Article
- Single nucleotide +1 frameshifts in an apparently functional mitochondrial cytochrome b gene in ants of the genus Polyrhachis.Journal of molecular evolution · 2005Article
- tRNA slippage at the tmRNA resume codon.RNA (New York, N.Y.) · 2004Article
- P-site tRNA is a crucial initiator of ribosomal frameshifting.RNA (New York, N.Y.) · 2004Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
During translation, a string of non-overlapping triplet codons in messenger RNA is decoded into protein. The ability of a ribosome to decode mRNA without shifting between reading frames is a strict requirement for accurate protein biosynthesis. Despite enormous progress in understanding the mechanism of transfer RNA selection, the mechanism by which the correct reading frame is maintained remains unclear. In this report, evidence is presented that supports the idea that the translational frame is controlled mainly by the stability of codon-anticodon interactions at the P site. The relative instability of such interactions may lead to dissociation of the P-site tRNA from its codon, and formation of a complex with an overlapping codon, the process known as P-site tRNA slippage. We propose that this process is central to all known cases of +1 ribosomal frameshifting, including that required for the decoding of the yeast transposable element Ty3. An earlier model for the decoding of this element proposed 'out-of-frame' binding of A-site tRNA without preceding P-site tRNA slippage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.