ArticleOncogene2003
Bfl-1S, a novel alternative splice variant of Bfl-1, localizes in the nucleus via its C-terminus and prevents cell death.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Anti-apoptotic BCL-2 family proteins: from regulatory networks to therapeutic targeting.Oncogenesis · 2026Review
- Last but not least: BFL-1 as an emerging target for anti-cancer therapies.Biochemical Society transactions · 2022Review
- BCL-2 family isoforms in apoptosis and cancer.Cell death & disease · 2019Review
- The pro-apoptotic BAX protein influences cell growth and differentiation from the nucleus in healthy interphasic cells.Cell cycle (Georgetown, Tex.) · 2017Article
- The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells.Biochimica et biophysica acta · 2013Article
- A1/Bfl-1 in leukocyte development and cell death.Experimental cell research · 2012Review
- BCL2A1: the underdog in the BCL2 family.Cell death and differentiation · 2012Review
- The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1.Molecular cancer · 2011Article
- Bim nuclear translocation and inactivation by viral interferon regulatory factor.PLoS pathogens · 2010Article
- Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma.Blood · 2010Article
- Expression and function of bcl-2 proteins in melanoma.Current genomics · 2008Article
- The role of peptide motifs in the evolution of a protein network.Nucleic acids research · 2007Article
- Highly conserved caspase and Bcl-2 homologues from the sea anemone Aiptasia pallida: lower metazoans as models for the study of apoptosis evolution.Journal of molecular evolution · 2006Article
- Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.The Journal of clinical investigation · 2005Article
- Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bfl-1 is an antiapoptotic Bcl-2 family member and a mouse A1 homologue. The mouse A1 has been reported to have three isoforms, but little is known about human Bfl-1. By reverse-transcriptase polymerase chain reaction analysis, we have identified Bfl-1S (short form), an alternative splice variant of Bfl-1. The Bfl-1S primary sequence contains four conserved Bcl-2 homology (BH) domains and a positive-charged C-terminus containing KKRK amino acids. The expression of Bfl-1S mRNA was detected predominantly in normal lymph nodes and in B-lymphoid leukemia cells. Confocal microscopic analysis using green fluorescence protein fusion proteins demonstrated that Bfl-1S is localized in the nucleus by its C-terminus as an intrinsic nuclear localization sequence. Bfl-1S acts as an antiapoptotic agent in coexpression experiments with Bax, a proapoptotic molecule. The expression of Bfl-1S provided significant resistance against staurosporine (STS) treatments in Molt-4 human T-leukemia cells. Bfl-1S also significantly inhibited the cleavage of Bid, and of caspases 3 and 8 against STS treatment. These results indicate that Bfl-1S is a novel human Bcl-2 family member that possesses antiapoptotic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.