ArticleProceedings of the National Academy of Sciences of the United States of America2003
Characterization of the endokinins: human tachykinins with cardiovascular activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 161 citations in OpenAlex.
- The neuropeptide substance P regulates aldosterone secretion in human adrenals.Nature communications · 2020Trial
- PET-scan shows peripherally increased neurokinin 1 receptor availability in chronic tennis elbow: visualizing neurogenic inflammation?PloS one · 2013Trial
- Temporal expression profiles of tachykinin genes throughout the first reproductive cycle, male pregnancy, and brood pouch development in the big-belly seahorse (Hippocampus abdominalis).Fish physiology and biochemistry · 2026Article
- Regulation of Aldosterone Secretion by Substance P and the Neurokinin Type 1 Receptor in Aldosterone-Producing Adenomas.Journal of the American Heart Association · 2026Article
- Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN).Scientific reports · 2024Article
- Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.Frontiers in endocrinology · 2022Review
- Regulatory Peptides in Asthma.International journal of molecular sciences · 2021Review
- Novel Pituitary Actions of TAC4 Gene Products in Teleost.International journal of molecular sciences · 2021Article
- [Scientific reports · 2019Article
- Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.Physiological reviews · 2014Review
- Article
- Neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (MMP-2) and membrane type 1-matrix metalloproteinase (MT1-MMP).The Journal of biological chemistry · 2013Article
- A comparison of the effects of amide and acid groups at the C-terminus on the collision-induced dissociation of deprotonated peptides.Journal of the American Society for Mass Spectrometry · 2012Article
- Role of neurokinin-1 receptor in the initiation and maintenance of skin chronic inflammatory diseases.Immunologic research · 2011Article
- Expression and function of human hemokinin-1 in human and guinea pig airways.Respiratory research · 2010Article
- Tachykinins and Neurokinin Receptors in Bone Marrow Functions: Neural-Hematopoietic Link.Journal of receptor, ligand and channel research · 2010Article
- Neurokinin B and pre-eclampsia: a decade of discovery.Reproductive biology and endocrinology : RB&E · 2010Review
- Future innovations in anti-platelet therapies.British journal of pharmacology · 2008Review
- Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation.Blood · 2008Article
- The significance of substance P in physiological and malignant haematopoiesis.Journal of clinical pathology · 2007Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report four human tachykinins, endokinins A, B, C, and D (EKA-D), encoded from a single tachykinin precursor 4 gene that generates four mRNAs (alpha, beta, gamma, and delta). Tachykinin 4 gene expression was detected primarily in adrenal gland and in the placenta, where, like neurokinin B, significant amounts of EKB-like immunoreactivity were detected. EKA/B 10-mers displayed equivalent affinity for the three tachykinin receptors as substance P (SP), whereas a 32-mer N-terminal extended form of EKB was significantly more potent than EKA/B or SP. EKC/D, which possess a previously uncharacterized tachykinin motif, FQGLL-NH(2), displayed low potency. EKA/B displayed identical hemodynamic effects to SP in rats, causing short-lived falls in mean arterial blood pressure associated with tachycardia, mesenteric vasoconstriction, and marked hindquarter vasodilatation. Thus, EKA/B could be the endocrineparacrine agonists at peripheral SP receptors and there may be as yet an unidentified receptor(s) for EKC/D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.