ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 83 citations in OpenAlex.
- Serotonergic Suppression of Sustained Synaptic Responses in Rat Oculomotor Neural Integrator Networks.eNeuro · 2025Article
- Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Article
- Electrophysiological Properties of Proprioception-Related Neurons in the Intermediate Thoracolumbar Spinal Cord.eNeuro · 2024Article
- Techniques for Measurement of Serotonin: Implications in Neuropsychiatric Disorders and Advances in Absolute Value Recording Methods.ACS chemical neuroscience · 2023Review
- Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter.Translational psychiatry · 2023Article
- Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter.Research square · 2023Article
- Serotonergic regulation of bipolar cell survival in the developing cerebral cortex.Cell reports · 2022Article
- Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Overexpression of serotonin receptor 5b expression rescues neuronal and behavioral deficits in a mouse model of Kabuki syndrome.IBRO reports · 2020Article
- Serotonin abnormalities in Dravet syndrome mice before and after the age of seizure onset.Brain research · 2019Article
- 5-HTNeurobiology of stress · 2017Article
- Serotonin and brain function: a tale of two receptors.Journal of psychopharmacology (Oxford, England) · 2017Review
- Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Mechanisms of gain control by voltage-gated channels in intrinsically-firing neurons.PloS one · 2015Article
- Reducing substance use during adolescence: a translational framework for prevention.Psychopharmacology · 2014Review
- 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders.Frontiers in cellular neuroscience · 2014Review
- Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex.Frontiers in neural circuits · 2014Article
- Serotonin modulation of cortical neurons and networks.Frontiers in integrative neuroscience · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of serotonin (5-HT) on neuronal activity were examined during postnatal development in layer V pyramidal neurons of the rat prefrontal cortex (PFC) in vitro. Whole-cell patch-clamp recordings were made in slices obtained from rats aged between postnatal day (P) 6 and P31. In P14 or younger neurons, bath application of 5-HT (10 microM) induced a large depolarization followed by tonic firing at 2-5 Hz. The excitatory effects of 5-HT decreased rapidly after P14, so that by P21, 5-HT produced a small depolarization or hyperpolarization without cell firing. The excitatory effects of 5-HT at younger ages were attributed to 5-HT2A receptors because the effects were mimicked by the 5-HT2 agonist alpha-methyl-5-HT but not by the 5-HT3 agonist 1-(m-chlorophenyl)-biguanide, nor by the 5-HT2B/2C agonist 1-(3-chlorophenyl)piperazine, and were blocked by the 5-HT2A antagonists ketanserin and alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol. The excitatory responses persisted in 0 [Ca2+]o and high [Mg2+]o in the presence of TTX or blockers of ionotropic glutamate receptors, suggesting that the effects were mediated essentially by postsynaptic mechanisms. The responses to 5-HT involve a reduction of K+ conductance and an enhancement of the hyperpolarization-activated Na+/K+ current. The developmental decline of 5-HT-induced excitatory effects was associated with a downregulation of 5-HT2A receptor function and a decrease in the input resistance during early life. These results suggest that 5-HT is an important regulator of neuronal activity in the neonatal PFC and may play a role in activity-dependent developmental processes.
Indexed as
Identifiers
12716945PMC6742316W1597146577What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.