ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Independent sources of quantal variability at single glutamatergic synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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Who cites it
120 citing papers in PubMed, 233 citations in OpenAlex.
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- Synapse-specific structural plasticity that protects and refines local circuits during LTP and LTD.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Activity-dependent diffusion trapping of AMPA receptors as a key step for expression of early LTP.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Acute reorganization of postsynaptic GABACell reports · 2023Article
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- Pathway-Specific Remodeling of Thalamostriatal Synapses in a Mouse Model of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
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- Estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes.PLoS computational biology · 2022Article
- Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2021Review
- The glutamatergic synapse: a complex machinery for information processing.Cognitive neurodynamics · 2021Review
- Rapid Ultrastructural Changes in the PSD and Surrounding Membrane after Induction of Structural LTP in Single Dendritic Spines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength.Science advances · 2021Article
- Recordings from neuron-HEK cell cocultures reveal the determinants of miniature excitatory postsynaptic currents.The Journal of general physiology · 2021Article
- Shortened tethering filaments stabilize presynaptic vesicles in support of elevated release probability during LTP in rat hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The biophysical basis underlying the maintenance of early phase long-term potentiation.PLoS computational biology · 2021Article
- Nano-Organization at the Synapse: Segregation of Distinct Forms of Neurotransmission.Frontiers in synaptic neuroscience · 2021Review
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Variability in the size of single postsynaptic responses is a feature of most central neurons, although the source of this variability is not completely understood. The dominant source of variability could be either intersynaptic or intrasynaptic. To quantitatively examine this question, a biophysically realistic model of an idealized central axospinous synapse was used to assess mechanisms underlying synaptic variability measurements. Three independent sources of variability were considered: stochasticity of postsynaptic receptors ("channel noise"), variations of glutamate concentration in the synaptic cleft (Deltaq), and differences in the potency of vesicles released from different locations on the active zone [release-location dependence (RLD)]. As expected, channel noise was small (8% of the total variance) and Deltaq was the dominant source of variability (58% of total variance). Surprisingly, RLD accounted for a significant amount of variability (36%). Our simulations show that potency of release sites decreased with a length constant of approximately 100 nm, and that receptors were not activated by release events >300 nm away, which is consistent with the observation that single active zones are rarely >300 nm. RLD also predicts that the manner in which receptors are added or removed from synapses can dramatically affect the nature of the synaptic response, with increasing receptor density being more efficient than merely increasing synaptic area. Saturation levels and synaptic geometry were also important in determining the size and shape of the distribution of amplitudes recorded at different synapses.
Indexed as
Identifiers
12716926PMC2944019W2148126095What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.