ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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Who cites it
59 citing papers in PubMed, 130 citations in OpenAlex.
- Identification and Analysis of ZIC-Related Genes in Cerebellum of Autism Spectrum Disorders.Neuropsychiatric disease and treatment · 2024Article
- ErbB4 in parvalbumin-positive interneurons mediates proactive interference in olfactory associative reversal learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Contribution of Membrane Lipids to Postsynaptic Protein Organization.Frontiers in synaptic neuroscience · 2021Review
- Glutamate receptors and glutamatergic signalling in the peripheral nerves.Neural regeneration research · 2020Review
- Cocaine-Induced Synaptic Redistribution of NMDARs in Striatal Neurons Alters NMDAR-Dependent Signal Transduction.Frontiers in neuroscience · 2020Article
- Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity.Frontiers in physiology · 2020Review
- Neuregulin directed molecular mechanisms of visual cortical plasticity.The Journal of comparative neurology · 2019Review
- Rs7219 Regulates the Expression of GRB2 by Affecting miR-1288-Mediated Inhibition and Contributes to the Risk of Schizophrenia in the Chinese Han Population.Cellular and molecular neurobiology · 2019Article
- dbLGL: an online leukemia gene and literature database for the retrospective comparison of adult and childhood leukemia genetics with literature evidence.Database : the journal of biological databases and curation · 2018Article
- The Expression of Hippocampal NRG1/ErbB4 Correlates With Neuronal Apoptosis, but Not With Glial Activation During Chronic Cerebral Hypoperfusion.Frontiers in aging neuroscience · 2018Article
- How membrane dysfunction influences neuronal survival pathways in sphingolipid storage disorders.Journal of neuroscience research · 2016Review
- The reemergence of long-term potentiation in aged Alzheimer's disease mouse model.Scientific reports · 2016Article
- Calpain-Dependent ErbB4 Cleavage Is Involved in Brain Ischemia-Induced Neuronal Death.Molecular neurobiology · 2016Article
- Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex.The Journal of comparative neurology · 2014Article
- Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Review
- Processing of neuregulin-1 by neuropsin regulates GABAergic neuron to control neural plasticity of the mouse hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Acute neuregulin-1 signaling influences AMPA receptor mediated responses in cultured cerebellar granule neurons.Brain research bulletin · 2012Article
- Article
- ErbB4 localization to interneurons: clearer insights into schizophrenia pathology.Biological psychiatry · 2011Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
Abstract
Neuregulin (NRG) regulates synapse formation and synaptic plasticity, but little is known about the regulation of NRG signaling at synapses. Here we show that the NRG receptor ErbB4 was localized in anatomically defined postsynaptic densities in the brain. In cultured cortical neurons, ErbB4 was recruited to the neuronal lipid raft fraction after stimulation by NRG. Along with ErbB4, adaptor proteins Grb2 and Shc were translocated to lipid rafts by NRG stimulation. In transfected human embryonic kidney 293 cells, the partitioning of ErbB4 into a detergent-insoluble fraction that includes lipid rafts was increased by PSD-95 (postsynaptic density-95), through interaction of the ErbB4 C terminus with the PDZ [PSD-95/Discs large/zona occludens-1] domains of PSD-95. Disruption of lipid rafts inhibited NRG-induced activation of Erk and prevented NRG-induced blockade of induction of long-term potentiation at hippocampal CA1 synapses. Thus, our results indicate that NRG stimulation causes translocation of ErbB4 into lipid rafts and that lipid rafts are necessary for signaling by ErbB4.
Indexed as
Identifiers
12716924PMC6742330W1491692384What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.