ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Variable properties in a single class of excitatory spinal synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Synaptic input variation enhances rate coding at the expense of temporal precision in cochlear nucleus neurons.PLoS biology · 2026Article
- Neural heterogeneity as a unifying mechanism for efficient learning in spiking neural networks.Frontiers in computational neuroscience · 2025Article
- Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish.Nature communications · 2019Article
- Stationary-State Statistics of a Binary Neural Network Model with Quenched Disorder.Entropy (Basel, Switzerland) · 2019Article
- Multiple Two-Photon Targeted Whole-Cell Patch-Clamp Recordings From Monosynaptically Connected NeuronsFrontiers in synaptic neuroscience · 2019Article
- Variable synaptic strengths controls the firing rate distribution in feedforward neural networks.Journal of computational neuroscience · 2018Article
- The Lesioned Spinal Cord Is a "New" Spinal Cord: Evidence from Functional Changes after Spinal Injury in Lamprey.Frontiers in neural circuits · 2017Review
- The central pattern generator underlying swimming in Dendronotus iris: a simple half-center network oscillator with a twist.Journal of neurophysiology · 2016Article
- Distinct and developmentally regulated activity-dependent plasticity at descending glutamatergic synapses on flexor and extensor motoneurons.Scientific reports · 2016Article
- Short-Term Synaptic Plasticity at Interneuronal Synapses Could Sculpt Rhythmic Motor Patterns.Frontiers in neural circuits · 2016Article
- Firing rate dynamics in recurrent spiking neural networks with intrinsic and network heterogeneity.Journal of computational neuroscience · 2015Article
- Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses.Neural plasticity · 2015Article
- Axonal noise as a source of synaptic variability.PLoS computational biology · 2014Article
- Dynamic systems approaches and levels of analysis in the nervous system.Frontiers in physiology · 2013Article
- Atypical properties of release and short-term depression at a specialized nicotinic synapse in the Mauthner cell network.The Journal of experimental biology · 2011Article
- Locomotor rhythm maintenance: electrical coupling among premotor excitatory interneurons in the brainstem and spinal cord of young Xenopus tadpoles.The Journal of physiology · 2009Article
- Complexities and uncertainties of neuronal network function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Metaplastic facilitation and ultrastructural changes in synaptic properties are associated with long-term modulation of the lamprey locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Activity-dependent feedforward inhibition modulates synaptic transmission in a spinal locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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1 author.
Funding
Abstract
Although synaptic properties are specific to the type of synapse examined, there is evidence to suggest that properties can vary in individual synaptic populations. Here, a large sample of monosynaptic connections made by excitatory interneurons (EINs) onto motor neurons in the lamprey spinal cord locomotor network has been used to examine the properties of a single class of spinal synapse in detail. The properties and activity-dependent plasticity of EIN-evoked EPSPs varied considerably. This variability occurred at convergent inputs made by several EINs onto single motor neurons. This suggests that it was an intrinsic network property and not simply related to differences between animals or experiments. The activity-dependent plasticity of EIN-evoked EPSPs could be negatively or positively related to the initial EPSP amplitude (P1 and P2 connections, respectively). This reflected the development of facilitation and depression from either small or large initial EPSPs. To identify differences in presynaptic properties that could contribute to the synaptic variability, the quantal amplitude, release probability, number of release sites, and size of the available vesicle pool were examined. This analysis suggested that the variable amplitude and plasticity of EPSPs at P1 and P2 connections reflected an interaction between the release probability and the size of the available transmitter store. There is thus significant functional variability in EIN synaptic properties. Synapses ranged from strong (evoked postsynaptic spikes) to weak (small depressing EPSPs). The selection of interneurons with different synaptic properties could provide an intrinsic mechanism for modifying excitatory network interactions and the locomotor network output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.