ArticleArchives of disease in childhood2003
ISABEL: a web-based differential diagnostic aid for paediatrics: results from an initial performance evaluation.
Article in Archives of disease in childhood, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effectiveness of Electronic Differential Diagnoses (DDX) Generators: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Should electronic differential diagnosis support be used early or late in the diagnostic process? A multicentre experimental study of Isabel.BMJ quality & safety · 2022Trial
- Nurse Practitioner Students' Perceptions of an Artificial Intelligence Differential Diagnosis Tool: A Pilot Study.Journal of clinical nursing · 2026Article
- Cracking the code: a head-to-head comparison of expert clinicians and artificial intelligence in diagnosing rare diseases.Orphanet journal of rare diseases · 2025Article
- Rheumatology in the digital health era: status quo and quo vadis?Nature reviews. Rheumatology · 2024Review
- Large Language Models in the Diagnosis of Hand and Peripheral Nerve Injuries: An Evaluation of ChatGPT and the Isabel Differential Diagnosis Generator.Journal of hand surgery global online · 2024Article
- Retrieval-Based Diagnostic Decision Support: Mixed Methods Study.JMIR medical informatics · 2024Article
- Electronic Diagnostic Support in Emergency Physician Triage: Qualitative Study With Thematic Analysis of Interviews.JMIR human factors · 2022Article
- [Digital diagnostic support in rheumatology].Zeitschrift fur Rheumatologie · 2021Review
- Assessing the Performance of a New Artificial Intelligence-Driven Diagnostic Support Tool Using Medical Board Exam Simulations: Clinical Vignette Study.JMIR medical informatics · 2021Article
- Prognostic models will be victims of their own success, unless….Journal of the American Medical Informatics Association : JAMIA · 2019Article
- An open access medical knowledge base for community driven diagnostic decision support system development.BMC medical informatics and decision making · 2019Article
- Use of health information technology to reduce diagnostic errors.BMJ quality & safety · 2013Review
- SANDS: a service-oriented architecture for clinical decision support in a National Health Information Network.Journal of biomedical informatics · 2008Article
- Performance of a web-based clinical diagnosis support system for internists.Journal of general internal medicine · 2008Article
- Validation of a diagnostic reminder system in emergency medicine: a multi-centre study.Emergency medicine journal : EMJ · 2007Article
- Diagnostic omission errors in acute paediatric practice: impact of a reminder system on decision-making.BMC medical informatics and decision making · 2006Article
- Structured data entry for narrative data in a broad specialty: patient history and physical examination in pediatrics.BMC medical informatics and decision making · 2006Article
- Assessment of the potential impact of a reminder system on the reduction of diagnostic errors: a quasi-experimental study.BMC medical informatics and decision making · 2006Article
- Sharing patient information electronically throughout NHS: ability to provide seamless decision support will be key factor.BMJ (Clinical research ed.) · 2003Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo test the clinical accuracy of a web based differential diagnostic tool (ISABEL) for a set of case histories collected during a two stage evaluation.
methods
settingacute paediatric units in two teaching and two district general hospitals in the southeast of England. MATERIALS: sets of summary clinical features from both stages, and the diagnoses expected for these features from stage I (hypothetical cases provided by participating clinicians in August 2000) and final diagnoses for cases in stage II (children presenting to participating acute paediatric units between October and December 2000).
main outcome measurepresence of the expected or final diagnosis in the ISABEL output list.
resultsA total of 99 hypothetical cases from stage I and 100 real life cases from stage II were included in the study. Cases from stage II covered a range of paediatric specialties (n = 14) and final diagnoses (n = 55). ISABEL displayed the diagnosis expected by the clinician in 90/99 hypothetical cases (91%). In stage II evaluation, ISABEL displayed the final diagnosis in 83/87 real cases (95%).
conclusionISABEL showed acceptable clinical accuracy in producing the final diagnosis for a variety of real as well as hypothetical case scenarios.
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Registered trials
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