Trial reportArthritis research & therapy2003
Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology.
Trial report in Arthritis research & therapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 8 syntheses or guidelines pooled it, 337 citations in OpenAlex.
- Clinical Applicability of Autologous Chondrocyte Implantation for the Treatment of Osteochondral Defects: A Meta-analysis.Current rheumatology reviews · 2024Pooled it
- No superior surgical treatment for secondary osteochondral defects of the talus.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Pooled it
- The comparison between the different generations of autologous chondrocyte implantation with other treatment modalities: a systematic review of clinical trials.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Pooled it
- We do not have evidence based methods for the treatment of cartilage defects in the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2011Pooled it
- Autologous chondrocyte implantation for the treatment of cartilage lesions of the knee: a systematic review of randomized studies.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2010Pooled it
- Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee.The Cochrane database of systematic reviews · 2010Pooled it
- Treatment of focal articular cartilage defects in the knee: a systematic review.Clinical orthopaedics and related research · 2008Pooled it
- Pooled it
- Arthroscopic microfracture with atelocollagen augmentation for osteochondral lesion of the talus: a multicenter randomized controlled trial.BMC musculoskeletal disorders · 2020Trial
- Current treatments of isolated articular cartilage lesions of the knee achieve similar outcomes.Clinical orthopaedics and related research · 2012Trial
- MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome.Skeletal radiology · 2006Trial
- Actin-Bundling Protein, Fascin-1, as a Target of Osteoarthritis Progression.Cytoskeleton (Hoboken, N.J.) · 2025Review
- Engineered Osteochondral Scaffolds with Bioactive Cartilage Zone for Enhanced Articular Cartilage Regeneration.Annals of biomedical engineering · 2025Article
- Ultrahigh-field MRI: where it really makes a difference.Radiologie (Heidelberg, Germany) · 2024Review
- Lesion Size Location Dependency on Maximum Pressure in Osteochondral Defects: Experiments and Finite-Element Analysis.Orthopaedic journal of sports medicine · 2024Article
- Cartilage Integrity: A Review of Mechanical and Frictional Properties and Repair Approaches in Osteoarthritis.Healthcare (Basel, Switzerland) · 2024Review
- Choice of Protein, Not Its Amyloid-Fold, Determines the Success of Amyloid-Based Scaffolds for Cartilage Tissue Regeneration.ACS omega · 2023Article
- Suppressing Chondrocyte Hypertrophy to Build Better Cartilage.Bioengineering (Basel, Switzerland) · 2023Review
- Article
- Typical Complications After Cartilage Repair of the Ankle Using Autologous Matrix-Induced Chondrogenesis (AMIC).Foot & ankle orthopaedics · 2023Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autologous chondrocyte implantation is being used increasingly for the treatment of cartilage defects. In spite of this, there has been a paucity of objective, standardised assessment of the outcome and quality of repair tissue formed. We have investigated patients treated with autologous chondrocyte implantation (ACI), some in conjunction with mosaicplasty, and developed objective, semiquantitative scoring schemes to monitor the repair tissue using MRI and histology. Results indicate repair tissue to be on average 2.5 mm thick. It was of varying morphology ranging from predominantly hyaline in 22% of biopsy specimens, mixed in 48%, through to predominantly fibrocartilage, in 30%, apparently improving with increasing time postgraft. Repair tissue was well integrated with the host tissue in all aspects viewed. MRI scans provide a useful assessment of properties of the whole graft area and adjacent tissue and is a noninvasive technique for long-term follow-up. It correlated with histology (P = 0.02) in patients treated with ACI alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.