ArticleJournal of neurochemistry2003
Molecular profiling of midbrain dopamine regions in cocaine overdose victims.
Article in Journal of neurochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Alteration in AMPA receptor subunit expression and receptor binding among patients with addictive disorders: A systematic review of human postmortem studies.Neuropsychopharmacology reports · 2019Pooled it
- Pro-Inflammatory Protein PSCA Is Upregulated in Neurological Diseases and Targets β2-Subunit-Containing nAChRs.Biomolecules · 2025Article
- AMPA/kainate receptor activation within the prelimbic cortex is necessary for incubated cocaine-craving.Frontiers in psychiatry · 2025Article
- Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats.Psychopharmacology · 2021Article
- Exploratory locomotion, a predictor of addiction vulnerability, is oligogenic in rats selected for this phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cocaine-induced Changes in the Expression of NMDA Receptor Subunits.Current neuropharmacology · 2019Review
- Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration.Drug and alcohol dependence · 2017Article
- Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence.Translational psychiatry · 2015Article
- Cocaine-induced changes in NMDA receptor signaling.Molecular neurobiology · 2014Review
- Cocaine-and-Amphetamine Regulated Transcript (CART) peptide attenuates dopamine- and cocaine-mediated locomotor activity in both male and female rats: lack of sex differences.Neuropeptides · 2014Article
- Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys.Neuroscience letters · 2014Article
- Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.Addiction biology · 2014Article
- Biomarkers for the development of new medications for cocaine dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Review
- Gene expression in the addicted brain.International review of neurobiology · 2014Review
- Dopaminergic dysregulation in prefrontal cortex of rhesus monkeys following cocaine self-administration.Frontiers in psychiatry · 2013Article
- Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression.ISRN neurology · 2012Article
- Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future.Neuron · 2010Review
- Cocainomics: new insights into the molecular basis of cocaine addiction.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic cocaine use in humans and animal models is known to lead to pronounced alterations in neuronal function in brain regions associated with drug reinforcement. To evaluate whether the alterations in gene expression in cocaine overdose victims are associated with specific dopamine populations in the midbrain, cDNA arrays and western blotting were used to compare gene and protein expression patterns between cocaine overdose victims and age-matched controls in the ventral tegmental area (VTA) and lateral substantia nigra (l-SN). Array analysis revealed significant up-regulation of numerous transcripts in the VTA, but not in the l-SN, of cocaine overdose victims including NMDAR1, GluR2, GluR5 and KA2 receptor mRNA (p < 0.05). No significant alterations between overdose victims and controls were observed for GluR1, R3 or R4 mRNA levels. Correspondingly, western blot analysis revealed VTA-selective up-regulation of CREB (p < 0.01), NMDAR1 (p < 0.01), GluR2 (p < 0.05), GluR5 (p < 0.01) and KA2 (p < 0.05) protein levels of cocaine overdose victims. The present results indicate that selective alterations of CREB and certain ionotropic glutamate receptor (iGluR) subtypes appear to be associated with chronic cocaine use in humans in a region-specific manner. Moreover, as subunit composition determines the functional properties of iGluRs, the observed changes may indicate alterations in the excitability of dopamine transmission underlying long-term biochemical and behavioral effects of cocaine in humans.
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Registered trials
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