ArticleNeurochemical research2003
Effect of low pH on glutamate uptake and release in isolated presynaptic endings from rat brain.
Article in Neurochemical research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed.
- Acid-sensing ion channels in ischemic stroke: amplifying and constraining neuronal injury in a phase-specific framework.Pflugers Archiv : European journal of physiology · 2026Review
- Complexities, Benefits, Risks, and Clinical Implications of Sodium Bicarbonate Administration in Critically Ill Patients: A State-of-the-Art Review.Journal of clinical medicine · 2024Review
- The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients.Biomedicines · 2023Article
- Synaptic receptors for low pH in extracellular space: metabotropic receptors are an underestimated factor in stroke.Neural regeneration research · 2020Review
- Article
- Rescue of hyperexcitability in hippocampal CA1 neurons from Mecp2 (-/y) mouse through surface potential neutralization.PloS one · 2018Article
- Role of iron, zinc and reduced glutathione in oxidative stress induction by low pH in rat brain synaptosomes.SpringerPlus · 2014Article
- Influence of intra- and extracellular acidification on free radical formation and mitochondria membrane potential in rat brain synaptosomes.Journal of molecular neuroscience : MN · 2013Article
- Na-coupled bicarbonate transporters of the solute carrier 4 family in the nervous system: function, localization, and relevance to neurologic function.Neuroscience · 2010Review
- Presynaptic glycine receptors influence plasma membrane potential and glutamate release.Neurochemical research · 2010Article
- Influence of hypotonic shock on glutamate and GABA uptake in rat brain synaptosomes.Neurochemical research · 2004Article
- Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress.Molecular psychiatry · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of acidification of the incubation medium on the membrane potential and glutamate uptake and release was studied in isolated presynaptic neuronal endings (synaptosomes) from rat brain. Using the fluorescent probe diS-C3-(5), a rapid depolarization of plasma membrane was detected at pH 6.0, most probably as a result of the inhibition of the sodium pump and potassium channel blockade. The membrane potential decrease did not result in increase of basal efflux of glutamate. Glutamate release following K(+)-induced depolarization was decreased upon lowering pH to 6.0. Acidosis inhibited mainly calcium-dependent (vesicular) release of glutamate and did not significantly reduce [14C]glutamate uptake. This inhibition of glutamate release but not of glutamate uptake may be a mechanism of the protective effect of acidosis during brain ischemia.
Indexed as
Identifiers
12716022What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.