ArticleImmunogenetics2003
Characterization of a divergent non-classical MHC class I gene in sharks.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Allele co-segregation and haplotype diversity of MHC IIβ genes in the small-spotted catshark Scyliorhinus canicula.Immunogenetics · 2025Article
- Features of the CD1 gene family in rodents and the uniqueness of the immune system of naked mole-rat.Biology direct · 2024Article
- Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula).Scientific reports · 2023Article
- A Highly Complex, MHC-Linked, 350 Million-Year-Old Shark Nonclassical Class I Lineage.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- An Ancient, MHC-Linked, Nonclassical Class I Lineage in Cartilaginous Fish.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019Review
- Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species.Immunogenetics · 2018Article
- Evolution of innate-like T cells and their selection by MHC class I-like molecules.Immunogenetics · 2016Review
- Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.Immunological reviews · 2015Review
- Coevolution of T-cell receptors with MHC and non-MHC ligands.Immunological reviews · 2015Review
- Characterization of a non-classical MHC class II gene in the vulnerable Chinese egret (Egretta eulophotes).Immunogenetics · 2015Article
- CD1 and mycobacterial lipids activate human T cells.Immunological reviews · 2015Review
- Evolution of nonclassical MHC-dependent invariant T cells.Cellular and molecular life sciences : CMLS · 2014Review
- A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles.Immunogenetics · 2014Review
- Article
- The evolved functions of CD1 during infection.Current opinion in immunology · 2009Review
- Contrasting mode of evolution between the MHC class I genomic region and class II region in the three-spined stickleback (Gasterosteus aculeatus L.; Gasterosteidae: Teleostei).Immunogenetics · 2007Article
- Comparative genomics of major histocompatibility complexes.Immunogenetics · 2005Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sharks are the most ancient group of vertebrates known to possess members of the major histocompatibility complex (MHC) gene family. For this reason, sharks provide a unique opportunity to gain insight into the evolution of the vertebrate immune system through comparative analysis. Two genes encoding proteins related to the MHC class I gene family were isolated from splenic cDNA derived from spiny dogfish shark ( Squalus acanthias). The genes have been designated MhcSqac-UAA*01 and MhcSqac-UAA*NC1. Comparative analysis demonstrates that the Sqac-UAA*01 protein sequence clusters with classical MHC class I of several shark species and has structural elements common to most classical MHC class I molecules. In contrast, Sqac-UAA*NC1 is highly divergent from all vertebrate classical MHC class I proteins, including the Sqac-UAA *01 sequence and those of other shark species. Although Sqac-UAA*NC1 is clearly related to the MHC class I gene family, no orthologous genes from other species were identified due to the high degree of sequence divergence. In fact, the Sqac NC1 protein sequence is the most divergent MHC class-I-like protein identified thus far in any shark species. This high degree of divergence is similar in magnitude to some of the MHC class-I-related genes found in mammals, such as MICA or CD1. These data support the existence of a class of highly divergent non-classical MHC class I genes in the most primitive vertebrates known to possess homologues of the MHC and other components of the adaptive immune system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.