ArticleImmunogenetics2003
Susceptibility to visceral leishmaniasis in the domestic dog is associated with MHC class II polymorphism.
Article in Immunogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- LeishVet guidelines for the practical management of canine leishmaniosis.Parasites & vectors · 2011Guideline
- Of cattle, sand flies and men: a systematic review of risk factor analyses for South Asian visceral leishmaniasis and implications for elimination.PLoS neglected tropical diseases · 2010Pooled it
- PacBio long-read amplicon sequencing of dog leukocyte antigen genes at full-length level in beagle dogs.Experimental animals · 2026Article
- Dog leukocyte antigen genotyping across class I and class II genes in beagle dogs as laboratory animals.Immunogenetics · 2024Article
- Within-host bayesian joint modeling of longitudinal and time-to-event data of Leishmania infection.PloS one · 2024Article
- Leishmaniosis in Greece: The Veterinary Perspective.Pathogens (Basel, Switzerland) · 2023Article
- Signalment, Immunological and Parasitological Status and Clinicopathological Findings ofAnimals : an open access journal from MDPI · 2023Article
- The immune response in canine and human leishmaniasis and how this influences the diagnosis- a review and assessment of recent research.Frontiers in cellular and infection microbiology · 2023Review
- Immune and Genomic Analysis of Boxer Dog Breed and Its Relationship withVeterinary sciences · 2022Article
- Positive selection on the MHC class II DLA-DQA1 gene in golden jackals (Canis aureus) from their recent expansion range in Europe and its effect on their body mass index.BMC ecology and evolution · 2021Article
- Exploring the relationship between susceptibility to canine leishmaniosis and anti-Phlebotomus perniciosus saliva antibodies in Ibizan hounds and dogs of other breeds in Mallorca, Spain.Parasites & vectors · 2020Article
- Association between canine leishmaniosis and Ehrlichia canis co-infection: a prospective case-control study.Parasites & vectors · 2018Article
- Cytokine Effect of TLR3, TLR4, and TLR7 Agonists Alone or Associated withBioMed research international · 2018Article
- Biomarkers Associated WithFrontiers in cellular and infection microbiology · 2018Review
- Genetic diversity and population structure of African village dogs based on microsatellite and immunity-related molecular markers.PloS one · 2018Article
- Canine Leishmaniasis: An Overview of the Current Status and Strategies for Control.BioMed research international · 2018Review
- A novel B- and helper T-cell epitopes-based prophylactic vaccine againstBioImpacts : BI · 2018Article
- Canine β-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs.Parasites & vectors · 2017Article
- Insights on adaptive and innate immunity in canine leishmaniosis.Parasitology · 2017Article
- MYD88 and functionally related genes are associated with multiple infections in a model population of Kenyan village dogs.Molecular biology reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zoonotic visceral leishmaniasis (VL) is a disease of dogs, humans and other animals caused by the intracellular macrophage parasite Leishmania infantum. We examined the relationship between DLA class II alleles ( DRB1, DQA1, DQB1) and the course of infection in a cohort of Brazilian mongrel dogs exposed to natural L. infantum infection. DLA alleles were typed by sequence-based typing. DLA-DRB1 genotype was significantly associated with levels of anti- Leishmania IgG and parasite status assessed by PCR. Dogs with DLA-DRB1*01502 had higher levels of specific IgG and an increased risk of being parasite positive compared with dogs without this allele, controlling for other alleles and significant variables. No significant associations were seen for DLA-DQA1 or DLA-DQB1 alleles. These results suggest that the DLA-DRB1 locus plays a role in determining susceptibility to canine VL. As the domestic dog is the main reservoir for human infection, the identification of genetic factors influencing canine resistance or susceptibility to VL may provide insights into the immunology and potential control through vaccination of VL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.