ArticleHistochemistry and cell biology2003
The mode of myofibril remodelling in human skeletal muscle affected by DOMS induced by eccentric contractions.
Article in Histochemistry and cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Chronic Adaptations to Eccentric Cycling Training: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- Pooled it
- Jaboticaba berry (Myrciaria jaboticaba) consumption improves plasma GSH levels and accelerates muscle recovery following exercise-induced muscle damage: a randomized, placebo-controlled trial.European journal of nutrition · 2025Trial
- Trial
- The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation - a study in healthy well-trained individuals after intensive resistance and endurance training.Journal of the International Society of Sports Nutrition · 2020Trial
- Re-evaluation of sarcolemma injury and muscle swelling in human skeletal muscles after eccentric exercise.PloS one · 2013Trial
- Strength training elevates HSP27, HSP70 and αB-crystallin levels in musculi vastus lateralis and trapezius.European journal of applied physiology · 2012Trial
- Local NSAID infusion inhibits satellite cell proliferation in human skeletal muscle after eccentric exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Trial
- Muscle injury after repeated bouts of voluntary and electrically stimulated exercise.Medicine and science in sports and exercise · 2008Trial
- Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running.The Journal of physiology · 2004Trial
- Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism.Science advances · 2026Article
- Quantification of Exercise-Induced Sarcomeric Damage in R349P Desmin Knock-In Mice: A New Approach in Myofibrillar Myopathy Research.Neuropathology and applied neurobiology · 2025Article
- Recycle, repair, recover: the role of autophagy in modulating skeletal muscle repair and post-exercise recovery.Bioscience reports · 2025Review
- Relationships between Changes in Muscle Shear Modulus, Urinary Titin N- Terminal Fragment, and Maximum Voluntary Contraction Torque after Eccentric Exercise of the Elbow Flexors.Journal of sports science & medicine · 2023Article
- The Effect of Contrast Water Therapy on Dehydration during Endurance Training Camps in Moderate-Altitude Environments.Sports (Basel, Switzerland) · 2023Article
- Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress.Cell and tissue research · 2023Article
- Resistance exercise: a mighty tool that adapts, destroys, rebuilds and modulates the molecular and structural environment of skeletal muscle.Physical activity and nutrition · 2023Article
- Changes in Muscle Shear Modulus and Urinary Titin N-Terminal Fragment after Eccentric Exercise.Journal of sports science & medicine · 2022Article
- Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis.Nutrients · 2022Review
- Evaluating the Effects of Increased Protein Intake on Muscle Strength, Hypertrophy and Power Adaptations with Concurrent Training: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myofibrillar Z-disc streaming and loss of the desmin cytoskeleton are considered the morphological hallmarks of eccentric contraction-induced injury. The latter is contradicted by recent studies where a focal increase of desmin was observed in biopsies taken from human muscles with DOMS. In order to determine the effects of eccentric contraction-induced alterations of the myofibrillar Z-disc, we examined the distribution of alpha-actinin, the Z-disc portion of titin and the nebulin NB2 region in relation to actin and desmin in DOMS biopsies. In biopsies taken 2-3 days and 7-8 days after exercise, we observed a significantly higher number of fibres showing focal areas lacking staining for alpha-actinin, titin and nebulin than in biopsies taken from control or 1 h after exercise. None of these proteins were part of Z-disc streamings but instead they were found in distinct patterns in areas characterised by altered staining for desmin and actin. These were preferentially seen in regions with increased numbers of sarcomeres in parallel myofibrils. We propose that these staining patterns represent different stages of sarcomere formation. These findings therefore support our previous suggestion that muscle fibres subjected to eccentric contractions adapt to unaccustomed activity by the addition of new sarcomeres.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.