ArticleBritish journal of pharmacology2003
Collagen-induced resistance to glucocorticoid anti-mitogenic actions: a potential explanation of smooth muscle hyperplasia in the asthmatic remodelled airway.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma.Science translational medicine · 2022Article
- Important lessons learned from studies on the pharmacology of glucocorticoids in human airway smooth muscle cells: Too much of a good thing may be a problem.Pharmacology & therapeutics · 2020Review
- FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD).Frontiers in cell and developmental biology · 2020Review
- Crosstalk Between Signaling Pathways Involved in the Regulation of Airway Smooth Muscle Cell Hyperplasia.Frontiers in pharmacology · 2019Review
- Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1.Respiratory research · 2014Article
- Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition.Journal of allergy · 2012Article
- Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1.British journal of pharmacology · 2009Article
- Vitamin D - a new treatment for airway remodelling in asthma?British journal of pharmacology · 2009Article
- Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle.American journal of respiratory cell and molecular biology · 2009Article
- An imbalance in C/EBPs and increased mitochondrial activity in asthmatic airway smooth muscle cells: novel targets in asthma therapy?British journal of pharmacology · 2009Review
- Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.The European respiratory journal · 2007Review
- Phimosis and topical steroids: new clinical findings.Pediatric surgery international · 2007Article
- Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling.British journal of pharmacology · 2006Article
- Stimulus-dependent glucocorticoid-resistance of GM-CSF production in human cultured airway smooth muscle.British journal of pharmacology · 2005Article
- Factors controlling airway smooth muscle proliferation in asthma.Current allergy and asthma reports · 2004Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoids (GCS) inhibit mitogenesis of airway smooth muscle (ASM) cells grown on plastic. We have now evaluated the effects of GCS on proliferation of ASM grown on extracellular matrix proteins (ECM) abundant in noninflamed airways (laminin) and in fibrotic asthmatic airways (collagen type I). Dexamethasone inhibited basic fibroblast growth factor (bFGF)-induced proliferation in cells maintained on laminin, but not collagen. Cells grown on collagen were resistant to the anti-mitogenic actions of fluticasone propionate. In addition, dexamethasone did not inhibit thrombin-induced proliferation. Thus, resistance induced by collagen is not dependent on the mitogen and appears to be a class effect on GCS. The inhibition of bFGF-induced granulocyte-macrophage colony-stimulating factor production was unaffected by the ECM type on which cells were grown. The impaired anti-mitogenic activity of GCS in cells maintained on collagen may be due to a lack of efficacy against the collagen-amplified mitogenesis, rather than any defect in responsiveness that is specific to glucocorticoid receptor mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.