The ups and downs of Gs- to Gi-protein switching.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. In Vitro Pharmacology of Mitragynine at α-Adrenoceptors.ACS chemical neuroscience · 2025
   Article
2. Compartmentalized cAMP signalling and control of cardiac rhythm.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
   Review
3. Selective activation of Gαob by an adenosine ANature communications · 2022
   Article
4. On the G protein-coupling selectivity of the native ABiochemical pharmacology · 2018
   Article
5. Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling.International journal of biological sciences · 2017
   Article
6. A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells.PloS one · 2016
   Article
7. A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.British journal of pharmacology · 2014
   Review
8. Stratified approaches to the treatment of asthma.British journal of clinical pharmacology · 2013
   Review
9. Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR).Methods in molecular biology (Clifton, N.J.) · 2010
   Article
10. Activation of Gi induces mechanical hyperalgesia poststress or inflammation.Neuroscience · 2009
    Article
11. Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells.The Journal of biological chemistry · 2008
    Article
12. Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008
    Article

Corrections and comments

• Comment on
  Cardiac-specific overexpression of human beta2 adrenoceptors in mice exposes coupling to both Gs and Gi proteins.2003

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as