ReviewJournal of neurovirology2003
An overview: Human polyomavirus JC virus and its associated disorders.
Review in Journal of neurovirology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Understanding the link between neurotropic viruses, BBB permeability, and MS pathogenesis.Journal of neurovirology · 2024Review
- Detection of Malawi polyomavirus sequences in secondary lymphoid tissues from Italian healthy children: a transient site of infection.Virology journal · 2016Article
- Diagnostic assays for polyomavirus JC and progressive multifocal leukoencephalopathy.Reviews in medical virology · 2016Review
- A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.Antiviral research · 2012Article
- Sequencing and analysis of JC virus DNA from natalizumab-treated PML patients.The Journal of infectious diseases · 2011Article
- Progressive multifocal leukoencephalopathy and other forms of JC virus disease.Nature reviews. Neurology · 2010Review
- Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission.International journal of cancer · 2010Article
- Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen.Virus research · 2009Article
- The role of polyomaviruses in human disease.Virology · 2009Review
- Internally controlled triplex quantitative PCR assay for human polyomaviruses JC and BK.Journal of clinical microbiology · 2008Article
- Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation.Journal of cellular physiology · 2008Review
- Viruses associated with human cancer.Biochimica et biophysica acta · 2008Review
- Detection and typing of BKV, JCV, and SV40 by multiplex nested polymerase chain reaction.Molecular biotechnology · 2007Article
- Cross-interaction between JC virus agnoprotein and human immunodeficiency virus type 1 (HIV-1) Tat modulates transcription of the HIV-1 long terminal repeat in glial cells.Journal of virology · 2006Article
- Role of JC virus agnoprotein in DNA repair.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
JC virus (JCV) is a polyomavirus infecting greater than 80% of the human population early in life. Replication of this virus in oligodendrocytes and astrocytes results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals, most notably acquired immunodeficiency syndrome (AIDS) patients. Moreover, recent studies have pointed to the association of JCV with a variety of brain tumors, including medulloblastoma. The JCV genome encodes for viral early protein, including large and small T antigens and the newly discovered isoform T', at the early phase of infection and the structural proteins VP1, VP2, and VP3 at the late stage of the lytic cycle. In addition, the late gene is responsible for the production of a small nonstructural protein, agnoprotein, whose function is not fully understood. Here, we have summarized some aspects of the JCV genome structure and function, and its associated diseases, including PML and brain tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.