Trial reportPediatric radiology2003
Sedation with midazolam for voiding cystourethrography in children: a randomised double-blind study.
Trial report in Pediatric radiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Midazolam for sedation before procedures.The Cochrane database of systematic reviews · 2016Pooled it
- Efficacy of a cartoon and photograph montage storybook in preparing children for voiding cystourethrogram.Pediatric radiology · 2013Trial
- Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography.Pediatric radiology · 2010Trial
- Premedication during micturating cystourethrogram to achieve sedation and anxiolysis.Pediatric nephrology (Berlin, Germany) · 2005Trial
- Voiding cystourethrography for the pediatric nephrologist: clinical value, challenges, and areas of debate.Pediatric nephrology (Berlin, Germany) · 2026Review
- Self-adjusted Nitrous Oxide During Urodynamic Studies Reduces Patient Pain Without Compromising Study Quality: A Randomized Controlled Trial.European urology open science · 2024Article
- Preoperative Videourodynamic Study Is Helpful in Predicting Long-term Postoperative Voiding Function in Asymptomatic Patients With Closed Spinal Dysraphism.International neurourology journal · 2022Article
- [Aspects of performing micturition urosonography, particularly sedation with midazolam].Der Radiologe · 2022Article
- Characteristics and Outcomes of Patients Receiving Sedation for Voiding Cystourethrography.Cureus · 2021Article
- Off-label drugs use in pediatric palliative care.Italian journal of pediatrics · 2018Article
- Use of sedative drugs at reducing the side effects of voiding cystourethrography in children.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- Utility of sedation for young children undergoing dimercaptosuccinic acid renal scans.Pediatric radiology · 2016Article
- Distress experienced during pediatric VCUGs - a granular, prospective assessment using the brief behavioral distress scale.Pediatric radiology · 2016Article
- Oral midazolam for voiding dysfunction in children undergoing voiding cystourethrography: a controlled randomized clinical trial.Nephro-urology monthly · 2014Article
- Urodynamic studies in spinal cord tethering.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
- Diagnostic accuracy of magnetic resonance voiding cystourethrography for detecting vesico-ureteral reflux in children and adolescents.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Sedation and the VCUG.Pediatric radiology · 2012Article
- Diagnosis and management of vesicoureteral reflux in children.Nature reviews. Urology · 2009Review
- Anxiety in children undergoing VCUG: sedation or no sedation?Advances in urology · 2008Article
- Sedation with nitrous oxide compared with no sedation during catheterization for urologic imaging in children.Pediatric radiology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSedation with midazolam facilitates the performance of diagnostic procedures in children, including voiding cystourethrography (VCUG). However, the influence of sedation on voiding and imaging results have not been adequately evaluated.
objectiveMidazolam and placebo were compared to assess discomfort during VCUG and to evaluate if sedation influenced the outcome of the examination. MATERIALS AND
methodsThe study was prospective, randomised and double-blind, and included 95 children, 48 in the midazolam group (median age 2.2 years) and 47 in the placebo group (median age 3.2 years). The evaluation included the child's/parent's experience of the VCUG, as well as the examination results.
resultsThe children/parents in the midazolam group experienced the VCUG as less distressing compared to those in the placebo group ( P<0.001). Forty-six of 48 children sedated with midazolam could void during the imaging procedure compared to 38 of 47 children given placebo ( NS). There was no difference in frequency or grade of vesicoureteric reflux or bladder emptying between the groups.
conclusionsWhen sedation is required to perform VCUG in children, midazolam can be used without negative effect on the outcome of the examination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.