ArticleJAMA
Stopping medical research to save money: a broken pact with researchers and patients.
2 registry-linked trialsAbstract readEditorialComment
In one paragraph
Article in JAMA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antihypertensive Drug/Gene Interactions and CV Events
Mutations, Hormone Therapy (HRT) and Venous Thromboembolism
Who cites it
24 citing papers in PubMed.
- Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Exoskeleton-based training improves walking independence in incomplete spinal cord injury patients: results from a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2023Trial
- Walking improvement in chronic incomplete spinal cord injury with exoskeleton robotic training (WISE): a randomized controlled trial.Spinal cord · 2022Trial
- Add-on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double-Blind Placebo-Controlled Study.Neurotoxicity research · 2018Trial
- Odon device for instrumental vaginal deliveries: results of a medical device pilot clinical study.Reproductive health · 2018Trial
- Laparoscopic versus conventional ileoanal pouch procedure in patients undergoing elective restorative proctocolectomy (LapConPouch Trial)-a randomized controlled trial.Langenbeck's archives of surgery · 2013Trial
- A safety evaluation of drotrecogin alfa (activated) in hematopoietic stem cell transplant patients with severe sepsis: lessons in clinical research.Bone marrow transplantation · 2005Trial
- What breaks when federal commitments break: comment on Beccia et al.SSM. Mental health · 2026Article
- Profiles of research waste in randomized clinical trials comparing de-escalation and escalation strategies for breast cancer treatment.Frontiers in oncology · 2026Article
- CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials.BMJ (Clinical research ed.) · 2025Article
- Discontinuation and nonpublication of clinical trials in orthopaedic oncology.Journal of orthopaedic surgery and research · 2024Article
- Public reporting of black participation in anti-hypertensive drug clinical trials.American heart journal · 2023Article
- Rates of discontinuation and non-publication of upper and lower extremity fracture clinical trials.Journal of orthopaedic surgery and research · 2023Article
- Predictive modeling of clinical trial terminations using feature engineering and embedding learning.Scientific reports · 2021Article
- Rates of Discontinuation and Nonpublication of Head and Neck Cancer Randomized Clinical Trials.JAMA otolaryngology-- head & neck surgery · 2020Article
- Article
- Wrongful termination: lessons from the Geron clinical trial.Stem cells translational medicine · 2014Article
- Economics and industry do not mean ethical conduct in clinical trials.Journal of pharmaceutical policy and practice · 2013Article
- Integrity in scientific publishing.Health services research · 2010Article
- CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials.BMJ (Clinical research ed.) · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Bruce M Psaty
Drummond Rennie
Funding
CALCIUM-CHANNEL BLOCKERS AND PRIMARY PREVENTION OF CHDR01HL043201 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1991 to 2004
$3.0MTRENDS IN THE USE OF CVD MEDICATIONS IN OLDER ADULTSR01AG009556 · NIA · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1993 to 2004
$2.1MMUTATIONS, HORMONE THERAPY, AND VENOUS THROMBOEMBOLISMR01HL060739 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1998 to 2001
$1.1MPOSTMENOPAUSE PROGESTINS, MI AND STROKER01HL040628 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1995 to 1997
–POSTMENOPAUSAL PROGESTINS &THE RISK OF CORONARY DISEASER29HL040628 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 1988 to 1992
–NHLBI NIH HHS HL40628NHLBI NIH HHS HL43201NHLBI NIH HHS HL60739NIA NIH HHS AG09556
Abstract
PubMed holds no abstract for this paper.
Indexed as
Adrenergic beta-AntagonistsAntihypertensive AgentsBenzothiadiazinesCalcium Channel BlockersClinical Trials as TopicDiureticsDrug IndustryHumansHypertensionOutcome Assessment, Health CareSodium Chloride Symporter InhibitorsVasodilator AgentsVerapamilAdrenergic beta-AntagonistsAntihypertensive AgentsBenzothiadiazinesCalcium Channel BlockersDiureticsSodium Chloride Symporter InhibitorsVasodilator AgentsVerapamilBiomedical and Behavioral Research
Identifiers
PMID
12709471What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT00005332ClinicalTrials.gov
NCT00005515ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.