ArticleAntimicrobial agents and chemotherapy2003
Chromosomal integration of a cephalosporinase gene from Acinetobacter baumannii into Oligella urethralis as a source of acquired resistance to beta-lactams.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
- Relative inhibitory activities of newly developed diazabicyclooctanes, boronic acid derivatives, and penicillin-based sulfone β-lactamase inhibitors against broad-spectrum AmpC β-lactamases.Antimicrobial agents and chemotherapy · 2024Article
- Dissemination of metaldehyde catabolic pathways is driven by mobile genetic elements in Proteobacteria.Microbial genomics · 2022Article
- Class C β-Lactamases: Molecular Characteristics.Clinical microbiology reviews · 2022Review
- How Do Transposable Elements Activate Expression of Transcriptionally Silent Antibiotic Resistance Genes?International journal of molecular sciences · 2022Review
- The Brief Case: Extragenitourinary Location of Oligella urethralis.Journal of clinical microbiology · 2019Article
- Database for the ampC alleles in Acinetobacter baumannii.PloS one · 2017Article
- Genetic environment of the KPC gene in Acinetobacter baumannii ST2 clone from Puerto Rico and genomic insights into its drug resistance.Journal of medical microbiology · 2016Article
- Novel Aminoglycoside Resistance Transposons and Transposon-Derived Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates.Antimicrobial agents and chemotherapy · 2016Article
- The Genetic Analysis of an Acinetobacter johnsonii Clinical Strain Evidenced the Presence of Horizontal Genetic Transfer.PloS one · 2016Article
- CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.Antimicrobial agents and chemotherapy · 2015Article
- Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities.Antimicrobial agents and chemotherapy · 2014Article
- The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.Frontiers in microbiology · 2012Article
- Extended-spectrum AmpC cephalosporinase in Acinetobacter baumannii: ADC-56 confers resistance to cefepime.Antimicrobial agents and chemotherapy · 2011Article
- Emergence of Escherichia coli sequence type ST131 carrying both the blaGES-5 and blaCTX-M-15 genes.Antimicrobial agents and chemotherapy · 2011Article
- Emergence and Distribution of Plasmids Bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii isolates in Taiwan.Antimicrobial agents and chemotherapy · 2010Article
- Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU.Antimicrobial agents and chemotherapy · 2010Article
- Genetic and biochemical characterization of the first extended-spectrum CARB-type beta-lactamase, RTG-4, from Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2009Article
- Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp.Antimicrobial agents and chemotherapy · 2008Article
- Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina.Antimicrobial agents and chemotherapy · 2007Article
- Dissemination of Acinetobacter baumannii clones with OXA-23 Carbapenemase in Colombian hospitals.Antimicrobial agents and chemotherapy · 2007Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical Oligella urethralis isolate COH-1, which was uncommonly resistant to penicillins and narrow-spectrum cephalosporins, was recovered from a 55-year-old patient with a urinary tract infection. Shotgun cloning into Escherichia coli and expression experiments gave recombinant clones expressing either an AmpC beta-lactamase-type phenotype of resistance or a carbenicillin-hydrolyzing beta-lactamase-type phenotype of resistance. The AmpC beta-lactamase identified (ABA-1), which had a pI value of 8.2, had 98% amino acid identity with a chromosomally encoded cephalosporinase of Acinetobacter baumannii. A 820-bp insertion sequence element, ISOur1, belonging to the IS6 family of insertion sequence elements, was identified immediately upstream of bla(ABA-1), providing a -35 promoter sequence and likely giving rise to a hybrid promoter region. The carbenicillin-hydrolyzing beta-lactamase identified (CARB-8), which had a pI value of 6.4, differed from CARB-5 by two amino acid substitutions. Hybridization of CeuI fragment I-restricted DNA fragments of O. urethralis COH-1 with bla(ABA-1)-, bla(CARB-8)-, and 16S rRNA-specific probes indicated the chromosomal integration of the beta-lactamase genes. PCR and hybridization experiments failed to detect bla(CARB-8)- and bla(ABA-1)-like genes in three O. urethralis reference strains, indicating that the beta-lactamase genes identified were the source of acquired resistance in O. urethralis COH-1. This is one of the few examples of the interspecies transfer and the chromosomal integration of a gene encoding a naturally occurring beta-lactamase.
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