ArticleImmunology2003
Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison.
Article in Immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- Friend or foe: assessing the value of animal models for facilitating clinical breakthroughs in complement research.The Journal of clinical investigation · 2025Review
- CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex.Brain sciences · 2024Article
- The proteome of the blood-brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture.Fluids and barriers of the CNS · 2024Article
- Mouse Sertoli Cells Inhibit Humoral-Based Immunity.International journal of molecular sciences · 2022Article
- Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits.Scientific reports · 2019Article
- Complement regulation and kidney diseases: recent knowledge of the double-edged roles of complement activation in nephrology.Clinical and experimental nephrology · 2018Review
- Article
- An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mouse Cd59b but not Cd59a is upregulated to protect cells from complement attack in response to inflammatory stimulation.Genes and immunity · 2015Article
- Epididymal C4b-binding protein is processed and degraded during transit through the duct and is not essential for fertility.Immunobiology · 2015Article
- Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury.The American journal of pathology · 2010Article
- Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice.The Journal of biological chemistry · 2010Article
- IgG subclasses and complement pathway in segmental and global membranous nephropathy.Pediatric nephrology (Berlin, Germany) · 2010Article
- Article
- The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility.Molecular immunology · 2008Article
- CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and -independent mechanisms.European journal of immunology · 2007Article
- Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
CD59, the sole membrane regulator of the membrane attack complex of complement, is broadly and abundantly expressed in man and other mammals. In mouse, CD59 is encoded by two homologous genes. The expression patterns and functional roles of the proteins encoded by these genes, mCD59a and mCD59b, have not been well characterized. Here we describe the generation of monoclonal and polyclonal antibodies detecting specifically mCD59a and mCD59b. These reagents have been used to study function and to ascertain the cell and tissue distributions of mCD59a and mCD59b. mCD59a was broadly distributed on endothelia, erythrocytes, platelets, and on numerous other cell types in organs, a distribution pattern resembling that of CD59 in other species. In marked contrast, expression of mCD59b was restricted to germ cell elements in the testis and mature spermatozoa. Both mCD59a and CD59b inhibited human and rodent complement with similar efficiency. These findings demonstrate that the broadly distributed mCD59a is the key regulator of the terminal complement pathway in mice whereas CD59b, expressed only in testis and on sperm, probably plays other roles in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.