ArticleMolecular and cellular biochemistry2003
Role of BSP/bilirubin binding protein on p-aminohippurate transport in rat kidney.
Article in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 13 citations in OpenAlex.
- Regulation of hepatic P-gp expression and activity by genistein in rats.Archives of toxicology · 2020Article
- Modulation of biotransformation systems and ABC transporters by benznidazole in rats.Antimicrobial agents and chemotherapy · 2013Article
- Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.World journal of gastroenterology · 2012Review
- Effect of glucagon-like peptide 2 on hepatic, renal, and intestinal disposition of 1-chloro-2,4-dinitrobenzene.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
- Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of Oatp1.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BSP/Bilirubin binding protein (BBBP) is a protein located on the sinusoidal membrane of the liver that transport several organic anions. The aim of this investigation was to determine whether BBBP is present in the kidney and its role in p-aminohippurate transport (PAH). Anti-BBBP antibodies inhibited PAH uptake in brush border membrane vesicles (BBMV) and Na(+)-independent PAH uptake in basolateral membrane vesicles (BLMV). Western blot studies revealed positivity to antiBBBP antibodies in both BBMV and BLMV. So BBBP is also expressed in the kidneys and accounts, at least in part, for the renal tubular transport of PAH.
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