ArticleClinical cardiology2003
Increased oxidative stress with elevated serum thioredoxin level in patients with coronary spastic angina.
Article in Clinical cardiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- [CT Imaging Findings in Non-Atherosclerotic Coronary Artery Disease].Taehan Yongsang Uihakhoe chi · 2022Review
- Association of Oxidative Stress with Neurological Disorders.Current neuropharmacology · 2022Article
- Imbalance in thioredoxin system activates NLRP3 inflammasome pathway in epicardial adipose tissue of patients with coronary artery disease.Molecular biology reports · 2021Article
- Non-atherosclerotic causes of acute coronary syndromes.Nature reviews. Cardiology · 2020Review
- The Biochemical Markers Associated with the Occurrence of Coronary Spasm.BioMed research international · 2019Review
- The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?Cellular and molecular life sciences : CMLS · 2018Review
- MECHANISTIC INSIGHTS OF CORONARY VASOSPASM AND NEW THERAPEUTIC APPROACHES.Fukushima journal of medical science · 2015Review
- Coronary artery spasm related to thiol oxidation and senescence marker protein-30 in aging.Antioxidants & redox signaling · 2013Article
- Oxidative stress: Predictive marker for coronary artery disease.Experimental and clinical cardiology · 2013Article
- Serum thioredoxin 1 level has close relation with myocardial damage amount in acute myocardial infarction patients.Journal of Korean medical science · 2012Article
- Penaeus monodon thioredoxin restores the DNA binding activity of oxidized white spot syndrome virus IE1.Antioxidants & redox signaling · 2012Article
- Redox regulation of cell survival by the thioredoxin superfamily: an implication of redox gene therapy in the heart.Antioxidants & redox signaling · 2009Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased oxidative stress has been implicated in the pathogenesis of coronary vasospasm. Thioredoxin (TRX) is a redox-active protein that is known to be induced by oxidative stress. HYPOTHESIS: The serum TRX level may be high in patients with coronary vasospasm.
methodsThe serum TRX level was determined using an enzyme-linked immunosorbent assay in 21 patients with the active stage of coronary spastic angina (CSA), in 18 patients with the inactive stage of CSA (iCSA), in 24 control subjects without coronary artery disease (Control), and in 20 patients with stable effort angina (SEA).
resultsSerum TRX levels (mean +/- standard deviation ng/ml) were significantly higher in CSA (64 +/- 44) than in iCSA (28 +/- 26), in Control (34 +/- 15), and in SEA (36 +/- 16). In contrast, serum alpha-tocopherol levels (mg/g lipids) were significantly lower in CSA (2.8 +/- 0.7) than in Control (4.0 +/- 1.2) and in SEA (3.2 +/- 0.4). Current smoking was significantly more prevalent in CSA (76%) than in any of the other groups. No significant correlation was found between the serum level of TRX and alpha-tocopherol in the study subjects. In nine patients with CSA, the serum TRX level decreased (93 +/- 41 --> 41 +/- 35 ng/ml) and the alpha-tocopherol level increased (2.7 +/- 0.6 --> 3.2 +/- 0.7 mg/g lipids) significantly under medication with calcium entry blockers after an at least 3-month angina-free period.
conclusionsPatients with coronary spastic angina had a higher serum TRX level associated with a lower serum level of antioxidant vitamin E, with redox equilibrium appearing to be related to the disease activity of coronary vasospasm in these patients. Oxidative stress may be related to the genesis of coronary vasospasm.
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