ArticleExperimental brain research2003
Secretory phospholipase A2 activity in the normal and kainate injected rat brain, and inhibition by a peptide derived from python serum.
Article in Experimental brain research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 42 citations in OpenAlex.
- Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels.Journal of natural products · 2017Article
- Migration of bone marrow progenitor cells in the adult brain of rats and rabbits.World journal of stem cells · 2016Review
- Endogenous phospholipase AThe journal of venomous animals and toxins including tropical diseases · 2016Review
- Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognition.Molecular neurobiology · 2014Article
- Expression and localization of sPLA2-III in the rat CNS.Neurochemical research · 2013Article
- Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Changes in brain cholesterol metabolome after excitotoxicity.Molecular neurobiology · 2010Review
- Differential effects of lysophospholipids on exocytosis in rat PC12 cells.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- sPhospholipase A(2) is inhibited by anthocyanidins.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.Arthritis research & therapy · 2009Article
- Role of secretory phospholipase a(2) in CNS inflammation: implications in traumatic spinal cord injury.CNS & neurological disorders drug targets · 2008Review
- Chronic intracerebroventricular delivery of the secretory phospholipase A2 inhibitor, 12-epi-scalaradial, does not improve outcome after focal cerebral ischemia-reperfusion in rats.Experimental brain research · 2007Article
- Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease.Journal of neuroinflammation · 2006Article
- Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study.Arthritis research & therapy · 2004Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to elucidate sPLA(2) activity in the normal and kainate-lesioned hippocampus using selective inhibitors of sPLA(2). In normal rats the highest levels of sPLA(2) were observed in the hippocampus, pons, and medulla, followed by the cerebral neocortex and caudate nucleus. After intracerebroventricular kainate injections an increase in total PLA(2) activity was observed in the rat hippocampus. Using a selective sPLA(2) inhibitor 12-epi-scalaradial, sPLA(2) activity was found to be significantly increased by 2.5-fold on the side of the intracerebroventricular injection compared to the contralateral side. A peptide P-NT.II, derived from the amino acid sequence of "PLA(2)-inhibitory protein," discovered in the serum of the reticulated python, also showed potent sPLA(2) inhibitory activity in homogenates from the kainate-injected hippocampus. These results show that there is a high level of sPLA(2) activity in the normal hippocampus, pons, and medulla oblongata, and that the level increases further in the hippocampus after kainate-induced excitotoxic injury. The increased PLA(2) activity was inhibited by P-NT.II, indicating a potential use of this peptide as a PLA(2) inhibitory agent in the brain.
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