ArticleThe Journal of molecular diagnostics : JMD2003
Chromosomal abnormalities in non-small cell lung carcinomas and in bronchial epithelia of high-risk smokers detected by multi-target interphase fluorescence in situ hybridization.
Article in The Journal of molecular diagnostics : JMD, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
- Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Detection of circulating genetically abnormal cells using 4-color fluorescence in situ hybridization for the early detection of lung cancer.Journal of cancer research and clinical oncology · 2021Article
- Microbiota Biomarkers for Lung Cancer.Diagnostics (Basel, Switzerland) · 2021Article
- Circulating Genetically Abnormal Cells Add Non-Invasive Diagnosis Value to Discriminate Lung Cancer in Patients With Pulmonary Nodules ≤10 mm.Frontiers in oncology · 2021Article
- Sputum long non-coding RNA biomarkers for diagnosis of lung cancer.Cancer biomarkers : section A of Disease markers · 2019Article
- Carcinogenesis as a Result of Multiple Inflammatory and Oxidative Hits: a Comprehensive Review from Tumor Microenvironment to Gut Microbiota.Neoplasia (New York, N.Y.) · 2018Review
- Integrating Circulating Immunological and Sputum Biomarkers for the Early Detection of Lung Cancer.Biomarkers in cancer · 2018Article
- Clinical Utility of Chromosomal Aneusomy in Individuals at High Risk of Lung Cancer.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2017Article
- Increased cell apoptosis in human lung adenocarcinoma andOncology letters · 2017Article
- A prediction model for distinguishing lung squamous cell carcinoma from adenocarcinoma.Oncotarget · 2017Article
- Article
- COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link.British journal of pharmacology · 2016Review
- Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection.Clinical epigenetics · 2016Article
- Sputum microRNA biomarkers for identifying lung cancer in indeterminate solitary pulmonary nodules.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Molecular sputum analysis for the diagnosis of lung cancer.British journal of cancer · 2013Review
- Unique FISH patterns associated with cancer progression of oral dysplasia.Journal of dental research · 2012Article
- Interphase cytogenetics of sputum cells for the early detection of lung carcinogenesis.Cancer prevention research (Philadelphia, Pa.) · 2010Review
- The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias.International journal of cancer · 2009Article
- The use of genetic markers to identify lung cancer in fine needle aspiration samples.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Human lung carcinogenesis is accompanied by complex chromosomal changes that may be detected in interphase cells by fluorescence in situ hybridization (FISH) assay using recently developed multitarget DNA probes. Touch preparations of 20 non-small cell lung carcinomas, sputum specimens from 3 patients with lung cancer and from 11 ex-smokers without lung cancer, and cultured benign bronchial epithelium of 42 high-risk smokers, 9 of whom had concurrent invasive carcinoma, were tested using a four-color FISH probe (LAVysion) targeting centromere 6, 5p15.2, 7p12 (EGFR), and 8q24 (MYC). Significantly high frequencies of abnormal cells were found in each of the 20 NSCLC (100%) and in the 3 sputum specimens from lung cancer patients. None of the cytologically normal sputa contained FISH abnormalities. Cultured bronchial epithelial cells from 11 of 42 patients (26%) were abnormal for at least one probe. Abnormal FISH patterns had no association with gender, presence of tumor or histology. Multicolor FISH can readily detect chromosomal abnormalities in imprints and sputa from lung carcinomas. Chromosomal aneusomy is also frequent in bronchial epithelial cells from long-term smokers. The prognostic significance of the multicolor LAVysion FISH probe set should be validated in a controlled clinical trial.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.