ArticleThe Journal of cell biology2003
Spatial distribution and specification of mammalian replication origins during G1 phase.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Modeling the Dynamics of Eukaryotic DNA Synthesis in Remembrance of Tunde Ogunnaike.Industrial & engineering chemistry research · 2023Article
- Control of DNA replication timing in the 3D genome.Nature reviews. Molecular cell biology · 2019Review
- Article
- Genome Duplication: The Heartbeat of Developing Organisms.Current topics in developmental biology · 2016Review
- Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells.The Journal of biological chemistry · 2015Article
- USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator.PLoS biology · 2012Article
- Eukaryotic DNA replication origins: many choices for appropriate answers.Nature reviews. Molecular cell biology · 2010Review
- Clusters, factories and domains: The complex structure of S-phase comes into focus.Cell cycle (Georgetown, Tex.) · 2010Article
- Domain-wide regulation of DNA replication timing during mammalian development.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.Molecular biology of the cell · 2009Article
- Replication timing and transcriptional control: beyond cause and effect--part II.Current opinion in genetics & development · 2009Review
- A model for DNA replication showing how dormant origins safeguard against replication fork failure.EMBO reports · 2009Article
- [Establishment of spatial and temporal program for mammalian chromosome replication].Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme · 2009Review
- Global reorganization of replication domains during embryonic stem cell differentiation.PLoS biology · 2008Article
- DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts.Nucleic acids research · 2008Article
- Global regulation of genome duplication in eukaryotes: an overview from the epifluorescence microscope.Chromosoma · 2008Review
- Review
- Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin.The Journal of cell biology · 2006Article
- The functional role of Cdc6 in S-G2/M in mammalian cells.EMBO reports · 2006Article
- Visualization of bidirectional initiation of chromosomal DNA replication in a human cell free system.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have examined the distribution of early replicating origins on stretched DNA fibers when nuclei from CHO cells synchronized at different times during G1 phase initiate DNA replication in Xenopus egg extracts. Origins were differentially labeled in vivo versus in vitro to allow a comparison of their relative positions and spacing. With nuclei isolated in the first hour of G1 phase, in vitro origins were distributed throughout a larger number of DNA fibers and did not coincide with in vivo origins. With nuclei isolated 1 h later, a similar total number of in vitro origins were clustered within a smaller number of DNA fibers but still did not coincide with in vivo origins. However, with nuclei isolated later in G1 phase, the positions of many in vitro origins coincided with in vivo origin sites without further change in origin number or density. These results highlight two distinct G1 steps that establish a spatial and temporal program for replication.
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Registered trials
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