ArticleThe Journal of experimental medicine2003
Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 158 citations in OpenAlex.
- Disruption of post-thymic tolerance in skin-reactive TCR transgenic mice through the interaction of lymphopenia and intestinal microbiota.International immunology · 2024Article
- Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans.JCI insight · 2023Article
- Proper development of long-lived memory CD4 T cells requires HLA-DO function.Frontiers in immunology · 2023Article
- Memory-phenotype CD4+ T cells: a naturally arising T lymphocyte population possessing innate immune function.International immunology · 2022Review
- Homeostasis of Naive and Memory T Lymphocytes.Cold Spring Harbor perspectives in biology · 2021Review
- Regulatory T Cells Fail to Suppress Fast Homeostatic Proliferation In Vitro.Life (Basel, Switzerland) · 2021Article
- Immune Equilibrium Depends on the Interaction Between Recognition and Presentation Landscapes.Frontiers in immunology · 2021Review
- Expansion of an Unusual Virtual Memory CD8Frontiers in immunology · 2021Article
- Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence.Cellular immunology · 2020Article
- CD5 and CD6 as immunoregulatory biomarkers in non-small cell lung cancer.Translational lung cancer research · 2020Article
- CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses.PloS one · 2019Article
- The BTLA-HVEM-CD5 Immunoregulatory Axis-An Instructive Mechanism Governing pTreg Cell Differentiation.Frontiers in immunology · 2019Review
- Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations.PloS one · 2019Article
- Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4Frontiers in immunology · 2019Article
- Alemtuzumab as Treatment for Multiple Sclerosis.Cold Spring Harbor perspectives in medicine · 2018Review
- Regulatory mechanisms in T cell receptor signalling.Nature reviews. Immunology · 2018Review
- The Confluence of Sex Hormones and Aging on Immunity.Frontiers in immunology · 2018Review
- Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4Blood advances · 2017Article
- Human neonatal thymectomy induces altered B-cell responses and autoreactivity.European journal of immunology · 2017Article
- T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.Scientific reports · 2017Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The requirements for survival and self-renewal of peripheral T cells and the nature of mechanisms controlling the size of the naive and memory pool are not completely understood. Here, we examine the involvement of the major histocompatibility complex (MHC) in survival and homeostatic expansion of naive and memory T cells. We show that the homeostatic behavior of naive T cell receptor (TCR)-transgenic T cells can be deduced by the expression levels of TCR and CD5, a negative regulator of TCR signaling. Both these factors determine the strength of TCR stimulation by MHC-derived signals. We further show that, similarly to naive T cells, MHC-derived signals influence the homeostatic expansion capacity of memory T cells under lymphopenic conditions. In contrast to naive T cells, however, memory T cells can reach a homeostatic equilibrium, in which survival/self-renewal of each clone is dissociated from their avidity for MHC-derived signals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.