ArticleThe American journal of pathology2003
Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis.BMC oral health · 2018Pooled it
- Pulmonary immunity and extracellular matrix interactions.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- A type 2 cytokine axis for thymus emigration.The Journal of experimental medicine · 2017Article
- 1,25-Dihydroxyvitamin D₃ Promotes High Glucose-Induced M1 Macrophage Switching to M2 via the VDR-PPARγ Signaling Pathway.BioMed research international · 2015Article
- Cellular mechanisms of tissue fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis.American journal of physiology. Cell physiology · 2014Review
- Silymarin reduces profibrogenic cytokines and reverses hepatic fibrosis in chronic murine schistosomiasis.Antimicrobial agents and chemotherapy · 2014Article
- Host responses in tissue repair and fibrosis.Annual review of pathology · 2013Review
- Transcriptional profiling of the bladder in urogenital schistosomiasis reveals pathways of inflammatory fibrosis and urothelial compromise.PLoS neglected tropical diseases · 2012Article
- FIZZ2/RELM-β induction and role in pulmonary fibrosis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Notch1 signaling in FIZZ1 induction of myofibroblast differentiation.The American journal of pathology · 2009Article
- Macrophages in hepatitis B and hepatitis C virus infections.Journal of virology · 2009Review
- IL-4R alpha expression by bone marrow-derived cells is necessary and sufficient for host protection against acute schistosomiasis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cationic amino acid transporter-2 regulates immunity by modulating arginase activity.PLoS pathogens · 2008Article
- Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.The American journal of pathology · 2007Article
- Infectious disease, the innate immune response, and fibrosis.The Journal of clinical investigation · 2007Review
- Treating very early rheumatoid arthritis.Best practice & research. Clinical rheumatology · 2006Review
- The IL-21 receptor augments Th2 effector function and alternative macrophage activation.The Journal of clinical investigation · 2006Article
- Focal interstitial CC chemokine receptor 7 (CCR7) expression in idiopathic interstitial pneumonia.Journal of clinical pathology · 2006Article
- Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin.Arthritis research & therapy · 2005Article
- Fibrotic disease and the T(H)1/T(H)2 paradigm.Nature reviews. Immunology · 2004Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Interleukin-13 (IL-13) has emerged as a major cytokine mediator of fibroblast activation and pulmonary fibrosis. Normal (from noninflamed lung), Th1-type (induced by the pulmonary embolization of purified peptide derivative-coated beads in mice sensitized to purified peptide derivative), and Th2-type (induced by the pulmonary embolization of Schistosoma mansoni egg antigen-coated beads in mice sensitized with S. mansoni eggs) primary fibroblast cell lines all exhibited constitutive gene expression of two receptor chains that bind and signal IL-13-mediated cellular events: IL-4Ralpha and IL-13Ralpha1. However, all three fibroblast cell lines exhibited divergent synthetic and proliferative responses to the exogenous addition of either recombinant IL-13 or a chimeric protein comprised of IL-13 and a truncated version of Pseudomonas exotoxin (IL13-PE), which targets and kills IL-13 receptor overexpressing cells. The exogenous addition of IL-13 to Th1-type and Th2-type fibroblast cultures significantly increased the cellular expression of IL-13Ralpha2, which may function as an IL-13 decoy receptor. After a 24-hour exposure to IL-13, the total collagen generation and cellular proliferation by Th2-type fibroblasts were significantly higher than that observed in similar numbers of normal and Th1-type fibroblasts. In addition IL13-PE, which binds with highest affinity to IL-13Ralpha2, exhibited down-regulatory effects on proliferation and matrix generation expression by Th1- and Th2-type, but not normal, fibroblasts. Thus, these data demonstrate that fibroblasts derived from murine pulmonary granulomas exhibit divergent expression of functional IL-13 receptor and this expression dictates the responsiveness and susceptibility to recombinant IL-13 and IL-13 immunotoxin, respectively.
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