ArticleThe American journal of pathology2003
Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Key genes and immune infiltration in chronic spontaneous urticaria: a study of bioinformatics and systems biology.Frontiers in immunology · 2023Article
- Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock.Biomedicines · 2022Article
- The Anti-inflammatory Effects of HMGB1 Blockades in a Mouse Model of Cutaneous Vasculitis.Frontiers in immunology · 2020Article
- Network of Mediators for Vascular Inflammation and Leakage Is Dysbalanced during Cytoreductive Surgery for Late-Stage Ovarian Cancer.Mediators of inflammation · 2019Article
- Polymorphisms in SELE gene and risk of coal workers' pneumoconiosis in Chinese: a case-control study.PloS one · 2013Article
- Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction.The American journal of pathology · 2010Article
- Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction.The American journal of pathology · 2009Article
- Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide.Clinical and experimental immunology · 2008Article
- Article
- Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses.The American journal of pathology · 2007Article
- E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis.The American journal of pathology · 2006Article
- Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.The American journal of pathology · 2005Article
- Role of adhesion molecules and dendritic cells in rat hepatic/renal ischemia-reperfusion injury and anti-adhesive intervention with anti-P-selectin lectin-EGF domain monoclonal antibody.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Immune complex-induced tissue injury is mediated by inflammatory cell infiltration that is highly regulated by multiple adhesion molecules. To assess the relative contribution of adhesion molecules, including selectins and ICAM-1, in this pathogenetic process, the cutaneous passive Arthus reaction was examined in mice lacking E-selectin, P-selectin, or both L-selectin and ICAM-1 with anti-P- or E-selectin mAbs. Edema and hemorrhage were significantly reduced in P-selectin(-/-) mice compared with wild-type mice while they were not inhibited in E-selectin(-/-) mice. Combined E- and P-selectin blockade resulted in more significant reduction relative to L-selectin/ICAM-1(-/-) as well as P-selectin(-/-) mice. Remarkably, both E- and P-selectin blockade in L-selectin/ICAM-1(-/-) mice completely abrogated edema and hemorrhage. The inhibited edema and hemorrhage paralleled reduced infiltration of neutrophils and mast cells that expressed significant levels of P-selectin glycoprotein ligand-1. Similarly reduced infiltration of neutrophils and mast cells was observed in the peritoneal Arthus reaction and was associated partly with the decreased production of tumor necrosis factor-alpha and interleukin-6. The results of this study indicate that both endothelial selectins contribute predominantly to the Arthus reaction by regulating mast cell and neutrophil infiltration and that the full development of the Arthus reaction is mediated cooperatively by all selectins and ICAM-1.
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