ArticleJournal of cellular biochemistry2003
Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells.
Article in Journal of cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 92 citations in OpenAlex.
- Maternal obesity driven changes in collagen linearity of breast extracellular matrix induces invasive mammary epithelial cell phenotype.Biomaterials · 2023Article
- Superoxide-induced Type I collagen secretion depends on prolyl 4-hydroxylases.Biochemical and biophysical research communications · 2020Article
- The Association of leptin with severity of non-alcoholic fatty liver disease: A population-based study.Clinical and molecular hepatology · 2018Article
- Expression patterns of STAT3, ERK and estrogen-receptor α are associated with development and histologic severity of hepatic steatosis: a retrospective study.Diagnostic pathology · 2018Article
- The pattern of IL-24/mda-7 and its cognate receptors expression following activation of human hepatic stellate cells.Biomedical reports · 2017Article
- Galanin receptor 2 mediates antifibrogenic effects of galanin on hepatic stellate cells.Experimental and therapeutic medicine · 2016Article
- Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis.Biochimica et biophysica acta · 2016Article
- STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis.RSC advances · 2016Article
- Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Article
- Loss of vitamin D receptor signaling from the mammary epithelium or adipose tissue alters pubertal glandular development.American journal of physiology. Endocrinology and metabolism · 2014Article
- Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Leptin and adiponectin: emerging therapeutic targets in breast cancer.Journal of mammary gland biology and neoplasia · 2013Review
- Glutathione synthesis.Biochimica et biophysica acta · 2013Review
- Translating an understanding of the pathogenesis of hepatic fibrosis to novel therapies.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Review
- Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis.The Biochemical journal · 2011Article
- Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes.Cellular & molecular biology letters · 2010Article
- Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation.World journal of gastroenterology · 2010Article
- Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3).Journal of cellular biochemistry · 2010Article
- Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.Hepatology (Baltimore, Md.) · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Leptin is a 16-kDa hormone with an array of biologic actions. We, and others, have demonstrated that leptin is critical to the development of liver fibrogenesis both in vitro and in the lean littermates of ob/ob mice exposed to carbon tetrachloride (CCl(4)). Controversy exists as to whether leptin can act as a direct cytokine in the development of increased collagen expression, and whether ob/ob mice are resistant to potential injury from CCl(4). Here, we provide evidence that strongly suggests that leptin acts to increase nascent production of mRNA for the alpha2(I) collagen gene based upon ribonuclease protection analysis (RPA). Actinomycin D, but not cyclohexamide, or the pan-neutralizing antibody to transforming growth factor beta one (TGFbeta1), significantly diminished the effect of leptin on total alpha2(I) collagen mRNA levels. Further evidence that leptin acts directly on HSCs to alter gene expression in liver wounding is demonstrated by enhanced binding of phosphorylated signal transduction and activator of transcription factor 3 (pStat3) to a cis-inducible element (SIE) oligonucleotide by electrophoretic mobility shift assay (EMSA). This consensus sequence is responsible for production of a critical collagen transcription factor, AP-1. Finally, we have demonstrated from the ob/ob mouse model that these animals are at least as sensitive to CCl(4) as their respective lean animals as assessed by serum alanine aminotransferase (ALT) measurements. Taken together, the current data provide a continued framework that leptin is a profibrogenic cytokine and plays a key role in liver fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.