ArticleAmerican journal of human genetics2003
A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Trial
- Sister haplotypes and recombination disequilibrium: a new approach to identify associations of haplotypes with complex diseases.Frontiers in genetics · 2023Article
- A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator.American journal of epidemiology · 2021Article
- Semiparametric analysis of complex polygenic gene-environment interactions in case-control studies.Biometrika · 2017Article
- A Note on Penalized Regression Spline Estimation in the Secondary Analysis of Case-Control Data.Statistics in biosciences · 2013Article
- Association of PON1 genotype and haplotype with susceptibility to coronary artery disease and clinical outcomes in dual antiplatelet-treated Han Chinese patients.European journal of clinical pharmacology · 2013Article
- Recursive organizer (ROR): an analytic framework for sequence-based association analysis.Human genetics · 2013Article
- Article
- Robust estimation for homoscedastic regression in the secondary analysis of case-control data.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2013Article
- Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk.Cancer epidemiology · 2012Article
- Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus.Arthritis and rheumatism · 2011Article
- The additive risk model for estimation of effect of haplotype match in BMT studies.Scandinavian journal of statistics, theory and applications · 2011Article
- Polymorphisms in nucleotide excision repair genes and endometrial cancer risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Article
- A Bayesian hierarchical model for detecting haplotype-haplotype and haplotype-environment interactions in genetic association studies.Human heredity · 2011Article
- Powerful multi-marker association tests: unifying genomic distance-based regression and logistic regression.Genetic epidemiology · 2010Article
- A general framework for studying genetic effects and gene-environment interactions with missing data.Biostatistics (Oxford, England) · 2010Article
- Associations between NBS1 polymorphisms, haplotypes and smoking-related cancers.Carcinogenesis · 2010Article
- A unified framework for detecting genetic association with multiple SNPs in a candidate gene or region: contrasting genotype scores and LD patterns between cases and controls.Human heredity · 2010Article
- Test selection with application to detecting disease association with multiple SNPs.Human heredity · 2010Article
- Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.PloS one · 2009Article
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3 authors.
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Abstract
The rough draft of the human genome map has been used to identify most of the functional genes in the human genome, as well as to identify nucleotide variations, known as "single-nucleotide polymorphisms" (SNPs), in these genes. By use of advanced biotechnologies, researchers are beginning to genotype thousands of SNPs from biological samples. Among the many possible applications, one of them is the study of SNP associations with complex human diseases, such as cancers or coronary heart diseases, by using a case-control study design. Through the gathering of environmental risk factors and other lifestyle factors, such a study can be effectively used to investigate interactions between genes and environmental factors in their associations with disease phenotype. Earlier, we developed a method to statistically construct individuals' haplotypes and to estimate the distribution of haplotypes of multiple SNPs in a defined population, by use of estimating-equation techniques. Extending this idea, we describe here an analytic method for assessing the association between the constructed haplotypes along with environmental factors and the disease phenotype. This method is also robust to the model assumptions and is scalable to a large number of SNPs. Asymptotic properties of estimations in the method are proved theoretically and are tested for finite sample sizes by use of simulations. To demonstrate the use of the method, we applied it to assess the possible association between apolipoprotein CIII (six coding SNPs) and restenosis by using a case-control data set. Our analysis revealed two haplotypes that may reduce the risk of restenosis.
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