ArticleInfection and immunity2003
Influence of Lewis antigen expression by Helicobacter pylori on bacterial internalization by gastric epithelial cells.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Internalization ofAnnals of medicine · 2026Review
- A large cohort study of the effects of Lewis, ABO, 13 other blood groups, and secretor status on COVID-19 susceptibility, severity, and long COVID-19.Transfusion · 2023Article
- Review
- Article
- Review
- The Possible Role ofFrontiers in oncology · 2019Review
- The Biosynthesis of Lipooligosaccharide frommBio · 2018Article
- Adhesion and Invasion of Gastric Mucosa Epithelial Cells byFrontiers in cellular and infection microbiology · 2016Review
- Human lactoferrin increases Helicobacter pylori internalisation into AGS cells.World journal of microbiology & biotechnology · 2012Article
- Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice.The Journal of experimental medicine · 2009Article
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
- Appropriate glycosylation of recombinant proteins for human use: implications of choice of expression system.Molecular biotechnology · 2004Review
- Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice.Antimicrobial agents and chemotherapy · 2003Article
- Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.The Journal of biological chemistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of Helicobacter pylori lipopolysaccharide (LPS) Lewis antigens in infection is still not well known. We investigated the influence of Lewis antigen expression by H. pylori on its internalization by AGS cells and the epithelium of human gastric xenografts in nude mice using isogenic mutants in LPS biosynthetic genes. In vivo, colonization rates were unaffected by the change in H. pylori Lewis antigen expression, whereas the number of viable intracellular bacteria was significantly higher with wild-type H. pylori strains expressing Lewis antigens when compared to the isogenic mutants in both models. H. pylori strains expressing more Lewis X antigens (Le(x)) were internalized at a higher rate than those expressing less Le(x), type II Lewis antigens (Le(a) or Le(b)) alone, or no Lewis antigens. Thus, Lewis antigens appear to be involved in the internalization of H. pylori by the gastric epithelium.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.