ArticleInfection and immunity2003
Gene expression profiling of Helicobacter pylori reveals a growth-phase-dependent switch in virulence gene expression.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Efficacy of 1% acetic acid in the treatment of chronic wounds infected with Pseudomonas aeruginosa: prospective randomised controlled clinical trial.International wound journal · 2016Trial
- How Salmonella Works Under Osmotic and Desiccation Stresses.Comprehensive reviews in food science and food safety · 2026Review
- Evaluation of antimicrobial and antibiofilm activities of peptide Impatiens balsamina-M1 and Zinc oxide nanoparticles against Helicobacter pylori.Scientific reports · 2025Article
- Pathogenicity and virulence ofVirulence · 2025Review
- An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology.Cell chemical biology · 2025Article
- First insight into the whole genome sequence variations in clarithromycin resistant Helicobacter pylori clinical isolates in Russia.Scientific reports · 2024Article
- Transcriptional and functional characterizations of multiple flagellin genes in spirochetes.Molecular microbiology · 2022Article
- Analysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors.Microbiology spectrum · 2022Article
- sRNA-mediated RNA processing regulates bacterial cell division.Nucleic acids research · 2021Article
- Effect of Temperature on Metronidazole Resistance inFrontiers in microbiology · 2021Article
- Transcriptional Profile ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.Microbiology and molecular biology reviews : MMBR · 2020Review
- A Vaginal Tract Signal Detected by the Group B Streptococcus SaeRS System Elicits Transcriptomic Changes and Enhances Murine Colonization.Infection and immunity · 2018Article
- ArsRS-Dependent Regulation ofFrontiers in microbiology · 2018Article
- BabA dependent binding of Helicobacter pylori to human gastric mucins cause aggregation that inhibits proliferation and is regulated via ArsS.Scientific reports · 2017Article
- Gene Expression Profiling of Transcription Factors ofFrontiers in microbiology · 2017Article
- Transcriptional Profiling of Type II Toxin-Antitoxin Genes ofFrontiers in microbiology · 2016Article
- The EPA2 adhesin encoding gene is responsive to oxidative stress in the opportunistic fungal pathogen Candida glabrata.Current genetics · 2015Article
- Crosstalk between the HpArsRS two-component system and HpNikR is necessary for maximal activation of urease transcription.Frontiers in microbiology · 2015Article
- Analysis of surface-exposed outer membrane proteins in Helicobacter pylori.Journal of bacteriology · 2014Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
The global pattern of growth-phase-dependent gene expression of Helicobacter pylori during in vitro culture was analyzed by using a high-density DNA microarray. To detect consistent coordinated gene expression in this bacterium, temporal changes in transcription were assessed in two independent time courses. Cluster analysis of the expression profiles highlighted a major switch in gene expression during the late log-to-stationary phase transition that we have termed the Log-Stat switch. Statistical analysis of the genes that were significantly induced or repressed during the Log-Stat switch revealed that many of these genes were related to virulence. Among these, expression of the genes for the neutrophil activating protein (napA) and the major flagellin subunit (flaA) were significantly induced. Additionally, the expression of a number of genes involved in iron homeostasis changed dramatically at this switch; the gene for the iron-storage protein, pfr, was induced, while the genes for two putative iron uptake proteins, fecA and frpB, were significantly repressed. These data suggest that the late log phase may correspond to the most virulent phase of growth in H. pylori and may be intimately related to its pathogenesis. The use of microarrays to analyze the kinetics of the transcriptional response of a bacterial pathogen to a changing environment has enabled the discovery of previously unappreciated relationships between genes by elucidation of coordinated gene expression profiles.
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