ArticleInfection and immunity2003
RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
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- Interplay Between Capsule Expression and Uracil Metabolism inFrontiers in microbiology · 2018Article
- ManLMN is a glucose transporter and central metabolic regulator in Streptococcus pneumoniae.Molecular microbiology · 2016Article
- Fifteen novel immunoreactive proteins of Chinese virulent Haemophilus parasuis serotype 5 verified by an immunoproteomic assay.Folia microbiologica · 2015Article
- Genomic reconstruction of transcriptional regulatory networks in lactic acid bacteria.BMC genomics · 2013Article
- Streptococcus pneumoniae can utilize multiple sources of hyaluronic acid for growth.Infection and immunity · 2012Article
- A functional genomics approach to establish the complement of carbohydrate transporters in Streptococcus pneumoniae.PloS one · 2012Article
- Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein.Molecular microbiology · 2011Article
- Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms.Nature methods · 2009Article
- Streptococcus adherence and colonization.Microbiology and molecular biology reviews : MMBR · 2009Review
- Pneumococcal surface protein A contributes to secondary Streptococcus pneumoniae infection after influenza virus infection.The Journal of infectious diseases · 2009Article
- The StkP/PhpP signaling couple in Streptococcus pneumoniae: cellular organization and physiological characterization.Journal of bacteriology · 2009Article
- Roles of rel(Spn) in stringent response, global regulation and virulence of serotype 2 Streptococcus pneumoniae D39.Molecular microbiology · 2009Article
- Sucrose metabolism contributes to in vivo fitness of Streptococcus pneumoniae.Molecular microbiology · 2007Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homolactic and catalase-deficient pathogen Streptococcus pneumoniae is not only tolerant to oxygen but requires the activity of its NADH oxidase, Nox, to develop optimal virulence and competence for genetic transformation. In this work, we show that the global regulator RegR is also involved in these traits. Genetic dissection revealed that RegR regulates competence and the expression of virulence factors, including hyaluronidase. In bacteria grown in vitro, RegR represses hyaluronidase. At neutral pH, it increases adherence to A549 epithelial cells, and at alkaline pH, it acts upstream of the CiaRH two-component signaling system to activate competence. These phenotypes are not associated with changes in antibiotic resistance, central metabolism, and carbohydrate utilization. Although the RegR(0) (where 0 indicates the loss of the protein) mutation is sufficient to attenuate experimental virulence of strain 23477 in mice, the introduction of an additional hyl(0) (where 0 indicates the loss of function) mutation in the RegR(0) strain 23302 dramatically reduces its virulence. This indicates that residual virulence of the RegR(0) Hyl(+) derivative is due to hyaluronidase and supports the dual role of RegR in virulence. This LacI/GalR regulator, not essential for in vitro growth in rich media, is indeed involved in the adaptive response of the pneumococcus via its control of competence, adherence, and virulence.
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