ArticleGenes & development2003
NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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84 citing papers in PubMed, 189 citations in OpenAlex.
- Expression pattern of the 10 mitogen-activated protein kinase kinases (MAPKK) encoded onPlant signaling & behavior · 2026Article
- A Rab/Kinesin-12/kinase module couples vesicle delivery and phragmoplast dynamics during plant cell cytokinesis.The EMBO journal · 2026Article
- Stress-induced MAPK (SIMK)-dependent organization of microtubules in alfalfa.Molecular horticulture · 2026Article
- Signaling Pathway Analysis and Downstream Genes Associated with Disease Resistance Mediated byPlants (Basel, Switzerland) · 2026Article
- A MAPK cascade regulates nuclear migration during female gametogenesis to establish specific cell identity and rice female fertility.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cellular dynamics and molecular signaling networks of plant cytokinesis.Molecules and cells · 2026Review
- From perception to action: MAPKs in plant-virus interactions.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Review
- Arabidopsis α-Aurora kinase plays a role in cytokinesis through regulating MAP65-3 association with microtubules at phragmoplast midzone.Nature communications · 2024Article
- Heat shock-induced failure of meiosis I to meiosis II transition leads to 2n pollen formation in a woody plant.Plant physiology · 2022Article
- A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis.Nature communications · 2022Article
- Regulatory Mechanisms of Mitogen-Activated Protein Kinase Cascades in Plants: More than Sequential Phosphorylation.International journal of molecular sciences · 2022Review
- Mitogen-Activated Protein Kinase and Substrate Identification in Plant Growth and Development.International journal of molecular sciences · 2022Review
- MAP kinase cascades in plant development and immune signaling.EMBO reports · 2022Review
- Integrative analysis of transcriptome and miRNAome reveals molecular mechanisms regulating pericarp thickness in sweet corn during kernel development.Frontiers in plant science · 2022Article
- The Protein Phosphatase PP2A Plays Multiple Roles in Plant Development by Regulation of Vesicle Traffic-Facts and Questions.International journal of molecular sciences · 2021Review
- Genome-wide identification, expression profiles and regulatory network of MAPK cascade gene family in barley.BMC genomics · 2019Article
- Noncanonical auxin signaling regulates cell division pattern during lateral root development.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- An RXLR effector secreted by Phytophthora parasitica is a virulence factor and triggers cell death in various plants.Molecular plant pathology · 2019Article
- A dual role for cell plate-associated PI4Kβ in endocytosis and phragmoplast dynamics during plant somatic cytokinesis.The EMBO journal · 2019Article
- Comparative analysis of plant MKK gene family reveals novel expansion mechanism of the members and sheds new light on functional conservation.BMC genomics · 2018Article
24 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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Abstract
The tobacco protein kinase NPK1 is a MAPKKK that regulates formation of the cell plate during cytokinesis. In the present study, we have identified tobacco NQK1/NtMEK1 and NRK1 as a MAPKK and a MAPK, respectively, downstream of NPK1. NQK1/NtMEK1 complements the mutation in the PBS2 MAPKK gene of yeast in a manner that depends on both NPK1 and its activator, NACK1, a kinesin-like protein. Active NPK1 and NQK1/NtMEK1 phosphorylate and activate NQK1/NtMEK1 and NRK1, respectively. Both NQK1/NtMEK1 and NRK1, as well as NPK1, are activated at the late M phase of the cell cycle in tobacco cells, and they are rapidly inactivated by depolymerization of phragmoplast microtubules. These results suggest the existence of a MAPK cascade that consists of NPK1, NQK1/NtMEK1, and NRK1 and functions in a process related to the architecture of phragmoplasts at the late M phase of the cell cycle. Overexpression of kinase-negative NQK1/NtMEK1 in tobacco cells generates multinucleate cells with incomplete cross-walls. Arabidopsis plants with a mutation in the ANQ1 gene, an ortholog of NQK1/NtMEK1, display a dwarf phenotype, with unusually large cells that contain multiple nuclei and cell-wall stubs in various organs. In addition, anq1 homozygotes set fewer flowers and produce large and malformed pollen grains with a tetrad structure. Thus, NQK1/NtMEK1 (ANQ1) MAPKK appears to be a positive regulator of plant cytokinesis during meiosis as well as mitosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.