ArticleGenetics2003
Fine mapping of complex trait genes combining pedigree and linkage disequilibrium information: a Bayesian unified framework.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Modeling allelic diversity of multiparent mapping populations affects detection of quantitative trait loci.G3 (Bethesda, Md.) · 2022Article
- Mapping genomic regions affecting milk traits in Sarda sheep by using the OvineSNP50 Beadchip and principal components to perform combined linkage and linkage disequilibrium analysis.Genetics, selection, evolution : GSE · 2019Article
- A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis.BioData mining · 2015Article
- Clusthaplo: a plug-in for MCQTL to enhance QTL detection using ancestral alleles in multi-cross design.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
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- Dissection of DNA damage responses using multiconditional genetic interaction maps.Molecular cell · 2013Article
- A fast expectation-maximum algorithm for fine-scale QTL mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Fine-mapping quantitative trait loci with a medium density marker panel: efficiency of population structures and comparison of linkage disequilibrium linkage analysis models.Genetics research · 2012Article
- Review
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- A gene frequency model for QTL mapping using Bayesian inference.Genetics, selection, evolution : GSE · 2010Article
- Article
- The impact of genetic relationship information on genomic breeding values in German Holstein cattle.Genetics, selection, evolution : GSE · 2010Article
- Linear models for joint association and linkage QTL mapping.Genetics, selection, evolution : GSE · 2009Article
- Estimating genealogies from linked marker data: a Bayesian approach.BMC bioinformatics · 2007Article
- Multipoint identity-by-descent prediction using dense markers to map quantitative trait loci and estimate effective population size.Genetics · 2007Article
- Article
- Article
- Linkage disequilibrium interval mapping of quantitative trait loci.BMC genomics · 2006Article
Corrections and comments
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1 author.
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Abstract
We present a Bayesian method that combines linkage and linkage disequilibrium (LDL) information for quantitative trait locus (QTL) mapping. This method uses jointly all marker information (haplotypes) and all available pedigree information; i.e., it is not restricted to any specific experimental design and it is not required that phases are known. Infinitesimal genetic effects or environmental noise ("fixed") effects can equally be fitted. A diallelic QTL is assumed and both additive and dominant effects can be estimated. We have implemented a combined Gibbs/Metropolis-Hastings sampling to obtain the marginal posterior distributions of the parameters of interest. We have also implemented a Bayesian variant of usual disequilibrium measures like D' and r(2) between QTL and markers. We illustrate the method with simulated data in "simple" (two-generation full-sib families) and "complex" (four-generation) pedigrees. We compared the estimates with and without using linkage disequilibrium information. In general, using LDL resulted in estimates of QTL position that were much better than linkage-only estimates when there was complete disequilibrium between the mutant QTL allele and the marker. This advantage, however, decreased when the association was only partial. In all cases, additive and dominant effects were estimated accurately either with or without disequilibrium information.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.