ArticleGenetics2003
Drosophila tufted is a gain-of-function allele of the proneural gene amos.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier.Development (Cambridge, England) · 2012Article
- Redundant mechanisms mediate bristle patterning on the Drosophila thorax.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos.BMC developmental biology · 2006Article
- Senseless acts as a binary switch during sensory organ precursor selection.Genes & development · 2003Article
- Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila.Genetics · 2003Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tufted is a classical Drosophila mutant characterized by a large number of ectopic mechanosensory bristles on the dorsal mesothorax. Unlike other ectopic bristle mutants, Tufted is epistatic to achaete and scute, the proneural genes that normally control the development of these sensory organs. In this report, I present genetic and molecular evidence that Tufted is a gain-of-function allele of the proneural gene amos that ectopically activates mechanosensory neurogenesis. I also systematically examine the ability of the various proneural bHLH proteins to cross-activate each other and find that their ability to do so is in general relatively limited, despite their common ability to induce the formation of mechanosensory bristles. This phenomenon seems instead to be related to their shared ability to activate Asense and Senseless.
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Registered trials
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