Trial reportPediatric nephrology (Berlin, Germany)2003
Early treatment with oral immunosuppressants in severe proteinuric purpura nephritis.
Trial report in Pediatric nephrology (Berlin, Germany), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- National recommendations for the management of children and young people with IgA vasculitis: a best available evidence, group agreement-based approach.Archives of disease in childhood · 2024Guideline
- Interventions for preventing and treating kidney disease in Henoch-Schönlein Purpura (HSP).The Cochrane database of systematic reviews · 2015Pooled it
- Henoch-Schönlein purpura nephritis: course of disease and efficacy of cyclophosphamide.Pediatric nephrology (Berlin, Germany) · 2004Trial
- Cyclosporin A for the treatment of severe Henoch-Schönlein glomerulonephritis.Pediatric nephrology (Berlin, Germany) · 2003Trial
- Efficacy and Safety of Tacrolimus in the Treatment of Pediatric Henoch-Schönlein Purpura Nephritis.Paediatric drugs · 2022Article
- Association of the clinicopathological characteristics and proteinuria remission of pediatric IgAV with nephrotic-range proteinuria: A retrospective cohort study.Frontiers in pediatrics · 2022Article
- A clinicopathological comparison between IgA nephropathy and Henoch-Schönlein purpura nephritis in children: use of the Oxford classification.Clinical and experimental nephrology · 2019Article
- Does MEST-C score predict outcomes in pediatric Henoch-Schönlein purpura nephritis?Pediatric nephrology (Berlin, Germany) · 2019Article
- Value of the Oxford classification of IgA nephropathy in children with Henoch-Schönlein purpura nephritis.Journal of nephrology · 2018Article
- Mycophenolate mofetil following glucocorticoid treatment in Henoch-Schönlein purpura nephritis: the role of early initiation and therapeutic drug monitoring.Pediatric nephrology (Berlin, Germany) · 2018Article
- Clinical features and outcomes of diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis in children.Clinics (Sao Paulo, Brazil) · 2016Article
- Pitfalls in recommending evidence-based guidelines for a protean disease like Henoch-Schönlein purpura nephritis.Pediatric nephrology (Berlin, Germany) · 2013Article
- Methylprednisolone pulse therapy and intravenous cyclophosphamide therapy combined with cocktail therapy in severe pediatric Henoch-Schönlein purpura nephritis patient.CEN case reports · 2013Article
- Treatment of children with Henoch-Schönlein purpura nephritis with mycophenolate mofetil.Pediatric nephrology (Berlin, Germany) · 2012Article
- Improved outcome of Henoch-Schonlein purpura nephritis by early intensive treatment.Indian journal of pediatrics · 2012Article
- Imbalance towards Th1 pathway predominance in purpura nephritis with proteinuria.Pediatric nephrology (Berlin, Germany) · 2011Article
- Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria.Pediatric nephrology (Berlin, Germany) · 2011Article
- Early treatment with methylprednisolone pulse therapy combined with tonsillectomy for heavy proteinuric henoch-schönlein purpura nephritis in children.Nephron extra · 2011Article
- Henoch-Schönlein purpura in childhood: treatment and prognosis. Analysis of 425 cases over a 5-year period.Clinical rheumatology · 2010Article
- Treatment-based literature of Henoch-Schönlein purpura nephritis in childhood.Pediatric nephrology (Berlin, Germany) · 2009Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nine Japanese children with severe proteinuric Henoch-Schönlein purpura nephritis (HSPN) received prompt initiation of oral prednisolone (1.5 mg/kg/day) combined with an 8-week course of cyclophosphamide (2 mg/kg/day) therapy. All underwent renal biopsy before and after treatment. At presentation, urine protein excretion and histologic indices of the mean activity index, the mean chronicity index and the tubulointerstitial (TI) scores in the patients were 5.0+/-1.4, 4.7+/-1.0, 3.9+/-1.6 and 3.7+/-0.5 g/day, respectively. Urine protein excretion, the activity index and the TI scores decreased significantly at the second renal biopsies obtained at a mean interval of 23 months after the first [0.3+/-0.3, 2.4+/-0.5 and 1.4+/-0.7 g/day ( P<0.01), respectively], while the chronicity index did not change. At the latest observation (mean interval 78 months), all except two showed negative proteinuria while no patient showed renal impairment. Although this case series is without controls, our experience suggests that early treatment with oral prednisolone and cyclophosphamide may be beneficial to a proportion of patients with severe proteinuric HSPN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.