ArticleVirchows Archiv : an international journal of pathology2003
Expression of vascular adhesion protein-1 in normal and inflamed mice lungs and normal human lungs.
Article in Virchows Archiv : an international journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- The use of exhaled air analysis in discriminating interstitial lung diseases: a pilot study.Respiratory research · 2022Observational
- The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model.British journal of pharmacology · 2016Article
- The role of JAM-B in cancer and cancer metastasis (Review).Oncology reports · 2016Review
- Feasibility of (68)Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome.American journal of nuclear medicine and molecular imaging · 2016Article
- Vascular adhesion protein 1 in the eye.Journal of ophthalmology · 2013Article
- Leukocyte adhesion molecules in diabetic retinopathy.Journal of ophthalmology · 2012Article
- Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization.Molecular vision · 2012Article
- Discovering collectively informative descriptors from high-throughput experiments.BMC bioinformatics · 2009Article
- Vascular adhesion protein-1 regulates leukocyte transmigration rate in the retina during diabetes.Experimental eye research · 2009Article
- Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Lipopolysaccharide induced inflammation in the perivascular space in lungs.Journal of occupational medicine and toxicology (London, England) · 2008Article
- Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in lipopolysaccharide-induced pulmonary inflammation.The American journal of pathology · 2006Article
- Strain-specific differences in perivascular inflammation in lungs in two murine models of allergic airway inflammation.Clinical and experimental immunology · 2005Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, vascular adhesion protein-1 (VAP-1) was implicated in adhesion and transmigration of lymphocytes across endothelial cells in liver and other organs. There is very little information on VAP-1 expression in normal and inflamed lungs. Therefore, we conducted a study to localize VAP-1 in normal mice and human lungs and in two distinct murine models of lung inflammation. Normal mice and human lungs revealed VAP-1 expression in the endothelium of large and mid-sized pulmonary vessels but not in alveolar septae, airway epithelium or blood cells. Mice that lack the lpr(-/-) gene and develop extensive lymphocytic infiltration in their lungs showed VAP-1 expression similar to the normal mice lungs. Mice subjected to cecal ligation and puncture developed acute lung inflammation and showed VAP-1 not only in endothelial cells but also in inflammatory cells in perivascular areas at 72 h after the procedure. We concluded that VAP-1 expression may contribute to the functional heterogeneity of endothelial cells within the lung to create distinct sites for the recruitment of inflammatory cells. Furthermore, since VAP-1 is expressed over a longer period of time in inflamed lungs, it may even be a suitable target for drug delivery and therapeutic manipulations.
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